基于阿尔茨海默病β-淀粉样蛋白发病机制探讨典型中药防治概况

Discussing the Overview of Typical Traditional Chinese Medicines in the Prevention and Treatment of Alzheimer's Disease Based on Pathogenesis of AmyloidβProtein

阿尔茨海默病(AD)是一种临床表现为学习记忆障碍、认知功能障碍、语言功能障碍的疾病,其发病机制复杂,其中β-淀粉样蛋白(Aβ)学说涵盖了氧化应激、炎症、细胞凋亡等多方面机制。该文基于Aβ机制以及相关信号通路,探讨典型中药及其有效成分预防和治疗AD的概况,以期为研发防治AD的中药提供思路和参考。

Alzheimer's disease(AD)is a disease with clinical manifestations of learning and memory impairment,cognitive dysfunction,and language dysfunction,the pathogenesis of AD is complex,of which Aβtheory covers various mechamisms such as oxidative stress,inflammation,apoptosis and other mechanisms.Based on the Aβmechanism and related signaling pathways,this study discusses the overview of typical Chinese medicines and their active ingredients in the prevention and treatment of AD.The aim is to provide insights and references for the development of traditional Chinese medicines for the prevention and treatment of AD.