m6A修饰调控酶及其结合蛋白在细胞自噬中作用的研究进展

Progress in role of m~6A modification regulatory enzymes and their binding proteins in cell autophagy

自噬可消除细胞内错误折叠或聚集的蛋白质、清除受损的细胞器以及降解不必要的细胞成分,对于维持细胞功能和新陈代谢十分重要[1]。自噬水平的异常在癌症、心血管、呼吸系统和神经退行性病变等疾病的发病机制中起到重要作用[2]。在过去几十年,对自噬的研究主要集中在自噬的调控机制及自噬基因的生物学功能[3-4]。

Autophagy is an important mechanism to maintain cellular function and metabolism,whereas abnormal autophagy can cause the advent and worsening of various diseases.N^6-Methyladenosine(m^6A)RNA methylation is a reversible RNA modification,which is regulated by m^6A methyltransferase,m^6A demethylase and m^6A-binding protein.Studies have shown that autophagy-related genes promote or attenuate autophagy level dependent on the regulation of m^6A,and then participate in the process of diseases.This paper reviews the progress of m^6A modification regulatory enzymes and their binding proteins in regulating cell autophagy to provide reference for future researches.