儿童人偏肺病毒流行病学研究进展

Progress on epidemiology of human metapneumovirus in children

人偏肺病毒(human metapneumovirus,hMPV)是引起儿童急性下呼吸道感染(acute lower respiratory infection,ALRI)的常见原因,尤其是2~5岁的儿童。研究并掌握hMPV各分型的流行特点及转化规律,可以对hMPV各亚型的分布地区、流行年份及临床相关性产生更深刻的认识。开展系统全面的hMPV基因分型及流行病学研究,揭示hMPV的分布特征、流行趋势有重要意义。该文对儿童hMPV流行病学的研究进展进行综述,为hMPV感染的监测、预防和临床治疗提供思路,为hMPV的疫苗研制和疾病防控提供参考依据。

Human metapneumovirus(hMPV)is a common cause of acute lower respiratory infection(ALRI)in children,especially in children aged 2~5 years.The study and mastery of the epidemiological characteristics and transformation patterns of various subtypes of hMPV can lead to a deeper understanding of the distribution areas,epidemiological years and clinical relevance of various subtypes of hMPV.It is important to carry out systematic and comprehensive genotyping and epidemiological study of hMPV to reveal the distribution characteristics and epidemic trend of hMPV.In this review,the research progress in the epidemiology of hMPV is reviewed,which provides ideas for the surveillance,prevention and clinical treatment of hMPV infection,and provides reference for the development of hMPV vaccine and disease prevention and control.