铁死亡在创伤性中枢神经系统损伤治疗中的研究进展

Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury

创伤性中枢神经系统损伤包括创伤性脑损伤和脊髓损伤,具有极高的致残率和死亡率,巨额的医疗费用和后遗症进一步加重了患者和家属的经济负担及心理负担。目前对创伤性中枢神经系统损伤的治疗包括手术疗法、物理疗法、药物治疗及后期康复治疗,但均不能取得理想的疗效,亟须更有效的治疗方法。铁死亡作为新近发现的程序性细胞死亡方式之一,被证实在创伤性中枢神经系统继发性损伤中发挥关键作用,但临床转化有限。本文通过总结抗中枢神经系统损伤铁死亡药物研究成果,分析铁死亡抑制剂的种类及作用结果,为临床治疗创伤性中枢神经系统损伤及药物开发提供新思路。

Traumatic central nervous system injury,including traumatic brain injury and spinal cord injury,has extremely high disability and mortality rates.The huge medical expenses and sequelae further aggravate the economic and psychological burden of patients and their families.Current treatments for traumatic central nervous system injury include surgical therapy,physical therapy,medication and post-rehabilitation treatment,but none of them can achieve ideal efficacy,and more effective treatment is urgently needed.Ferroptosis,as one of the newly discovered modes of programmed cell death,has been shown to play a crucial role in secondary injury to the traumatic central nervous system,but its clinical transformation is limited.This article summarizes the research results of ferroptosis inhibitors,points out the types and effects of them,to provide new ideas for clinical treatment of traumatic central nervous system injury and drug development.