汪悦教授应用肺肠合治法治疗原发性干燥综合征思路探析

Professor Wang Yue's Experience in Treating Primary Sjogren's Syndrome by Combined Treatment of Lung and Intestine

原发性干燥综合征(pSS)是以口眼干为主要表现。中医认为,该病属“燥痹”范畴,病机多为津液失常。古人素有“肺主通调水道”“大肠主津”“肺与大肠相表里”之说,汪悦教授在此基础上守正创新,应用肺肠合治法治疗原发性干燥综合征,通过麦冬地芍汤加减化裁治疗该病,取得良好疗效。麦冬地芍汤功擅“养肺布津,增液润肠”,在pSS的治疗中有着“肺肠同润,充盈水道”“三络同治,布散肺津”“脏腑同养,未病先防”的特点。基础研究表明麦冬地芍汤可能通过VIP/cAMP/PKA/AQP5信号通路发挥作用,附验案一则以资佐证。

Primary Sjogren's syndrome is characterized by dry mouth and eyes.According to traditional Chinese medicine,this disease belongs to the category of“dryness bi”,and its pathogenesis is mostly body fluid disorder.The ancients always said that“the lung dominating regulating water passage”,“the large intestine dominating fluid”,“interior-exterior relationship between lung and large intestine”.On this basis,Prof.Wang Yue kept innovating and proposed the treatment of primary Sjogren's syndrome with lung-intestinal combination and the treatment of MaiDongDiShao Decoction with modified cutting,which achieved good curative effect.This recipe is good at“nourishing lung Bujin,increasing fluid moistening intestine”,in the treatment of pSS has the characteristics of“lung intestine with moistening,filling the waterway”,“three collaterals with treatment,dispersing lung Jin”,“Zang-fu organs with nourishing,not disease prevention first”.Basic studies suggest that this party may play a role through the VIP/cAMP/PKA/AQP5 signaling pathway.A case for examination is attached.