重楼皂苷抗炎、抗氧化及抗肿瘤作用机制研究进展

Research progress on antioxidant,anti-inflammatory,and anti-tumor mechanisms of Rhizome Paridis saponins

重楼皂苷是重楼的主要活性成分,具有抗炎、抗氧化、抗肿瘤、抗菌、止血等多种药理作用。重楼皂苷抗炎作用的主要机制包括调控炎症因子、炎症细胞及相关信号转导通路等;其主要通过清除自由基、激活抗氧化酶活性、调节凋亡蛋白信号通路等发挥抗氧化作用;通过干扰相关信号通路、调控相关蛋白表达、抑制肿瘤细胞增殖、诱导周期阻滞、诱导肿瘤细胞程序性死亡、抑制肿瘤细胞转移与侵袭、抑制肿瘤血管的生成及抑制肿瘤耐药等机制发挥广谱抗肿瘤作用。针对重楼皂苷抗炎、抗氧化、抗肿瘤的作用机制进行综述,以期为深入研究和新药研发提供依据。

As an important natural saponin,Rhizome Paridis saponins is the main active ingredient of the traditional Chinese medicine Rhizome Paridis,which has a variety of pharmacological effects such as anti-inflammatory,antioxidant,anti-tumor,antibacterial and anti-inflammatory,and hemostatic.The anti-inflammatory effect of Rhizome Paridis saponin is characterized by multiple doctrines and pathways,and its main mechanism of action includes the regulation of inflammatory factors,inflammatory cells,and associated signal transduction pathways;Rhizome Paridis saponin mainly exerts antioxidant effects through scavenging free radicals,activating antioxidant enzyme activities,and regulating apoptotic protein signaling pathways;Rhizome Paridis saponin has spectral antitumor effects,exerting antitumor effects by interfering with related signaling pathways,regulating related protein expression,inhibiting tumor cell proliferation,inducing cycle blockade,inducing programmed death of tumor cells,inhibiting tumor cell metastasis and invasion,inhibiting tumor cardiovascular generation,and inhibiting tumor drug resistance,among other mechanisms.The present review specifically summarized the potential mechanisms of antioxidant,anti-inflammatory,and antitumor of Rhizome Paridis,in order to provide a reference for further research and drug development of Rhizome Paridis,and reference for their application in clinical treatment.