藏红花对2型糖尿病患者的心脏保护作用:一项系统综述和meta分析

Cardioprotective of Saffron(Crocus sativus L.)treatment in patients with type 2 diabetes mellitus:a systematic review and meta-analysis

目的探讨藏红花作为潜在补充剂在2型糖尿病患者治疗过程中的心脏保护作用。方法应用系统综述和meta分析优先报告条目(PRISMA)指南对Pub Med、Science Direct、Cochrane Library、Web of Science、中国知网(CNKI)和中国生物医学文献数据库(CBM)检索到的文章进行分析,发表时间跨度为2015年1月15日至2023年3月20日。本研究仅纳入英文随机对照试验(RCTs)文献,研究对象为接受藏红花或安慰剂治疗2型糖尿病的成年患者。采用Review Manager 5.4软件进行meta分析。本研究在国际前瞻性系统综述注册数据库(PROSPERO)中注册,注册号为CRD42023443180。结果本研究纳入了7项RCTs,包括455例患者。数据显示,与安慰剂相比,藏红花治疗显著降低了2型糖尿病患者的肿瘤坏死因子(TNF-α,P=0.008)和空腹血糖(FBG,P=0.04)水平。藏红花与安慰剂的白细胞介素6(IL-6)、丙二醛(MDA)、高血清C反应蛋白(hs-CRP)、血脂、血压和体重指数水平(BMI)差异均无统计学意义(P>0.05)。结论藏红花治疗通过降低肿瘤坏死因子和空腹血糖水平对2型糖尿病患者具有心脏保护作用。然而,这种植物化学物质的潜在抗氧化、抗高血压和抗血脂异常作用有待进一步研究。

Objective To investigate the cardioprotective effect of Saffron(Crocus sativus L.)treatment as a potential supplement on patients with type 2 diabetes mellitus(T2DM).Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines were applied to analyze articles retrieved from PubMed,ScienceDirect,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),and China Biology Medicine(CBM)with a publication time span from January 15,2015 to March 20,2023.The articles were published in English only,including randomized controlled trials(RCTs)on adult patients who were diagnosed with T2DM,and received either Saffron or placebo treatment.Meta-analysis was performed using Review Manager 5.4 software.The present study was registered on the International Prospective Register of Systematic Reviews(PROSPERO)with a registration number as CRD42023443180.Results Seven RCTs with 455 patients were included in the study.The data revealed that Saffron treatment significantly reduced tumor necrosis factor(TNF)-α(P=0.008)and fasting blood glucose(FBG)(P=0.04)levels compared with what placebo did in T2DM patients.No significant differences were shown in the levels of interleukin(IL)-6,malondialdehyde(MDA),high serum C-reactive protein(hs-CRP),lipid profile,blood pressure,and body mass index(BMI)between Saffron and placebo(P>0.05).Conclusion Saffron treatment has a cardioprotective effect in T2DM patients by reducing TNF-αand FBG levels.However,the potential anti-oxidant,anti-hypertensive,and anti-dyslipidaemia effects of the phytochemical need to be further investigated.