血清Sulfatide、ANGPTL4在急性心肌梗死合并心力衰竭中的表达

Expression of serum sulfatide and ANGPTL4 in acute myocardial infarction complicated with heart failure

目的分析血清硫苷脂(Sulfatide)、血管生成素样蛋白4(ANGPTL4)在急性心肌梗死合并心力衰竭中的表达情况。方法收集2021年6月至2022年4月于郑州大学第二附属医院心内科治疗的70例急性心肌梗死合并心力衰竭患者(AMI-HF组)和87例急性心肌梗死未合并心力衰竭的患者(AMI组)外周血,采用酶联免疫法(ELISA)检测两组血清Sulfatide和ANGPTL4水平;采用Logistic回归分析AMI患者发生心力衰竭的影响因素,采用Pearson分析血清Sulfatide和ANGPTL4水平与AMI-HF患者心功能指标的相关性,分析血清Sulfatide和ANGPTL4水平在评估AMI-HF疾病进展的应用价值。结果两组年龄、性别、心率、高血压、糖尿病、吸烟史比较,差异无统计学意义(P>0.05);AMI-HF组Sulfatide、LVEDVI、LVESVI均显著高于AMI组,ANGPTL4、LVEF低于AMI组,差异有统计学意义(P<0.05);Logistic回归分析发现,Sulfatide、ANGPTL4、LVEF、LVEDVI、LVESVI是AMI患者发生心力衰竭的影响因素(P<0.05);相关性分析结果显示,AMI-HF患者血清Sulfatide与LVEF呈显著负相关(P<0.05),与LVEDVI、LVESVI呈正相关(P<0.05);ANGPTL4与LVEF呈显著正相关(P<0.05),与LVEDVI、LVESVI呈负相关(P<0.05);AMI-HF患者中,预后良好组患者血清Sulfatide均显著低于预后不良组,ANGPTL4高于预后不良组,差异有统计学意义(P<0.05);血清Sulfatide和ANGPTL4联合预测AMI-HF预后价值高于单独检测(P<0.05)。结论监测AMI-HF患者血清Sulfatide和ANGPTL4水平可为疾病进展提供客观依据,血清Sulfatide和ANGPTL4二者还可为作为预测AMI-HF患者预后的重要指标。

Objective To analyze the expression of serum sulfatide and ANGPTL4 in patients with acute myocardial infarction complicated with heart failure.Methods Peripheral blood of 70 patients with acute myocardial infarction complicated with heart failure(AMI-HF group)and 87 patients with acute myocardial infarction without complicated heart failure(AMI group)treated in the Cardiology Department of the Second Affiliated Hospital of Zhengzhou University from June 2021 to April 2022 were collected.Serum sulfatide and ANGPTL4 levels were detected by enzyme-linked immunoassay(ELISA).Logistic regression was used to analyze the influencing factors of heart failure in AMI patients,and Pearson was used to analyze the correlation between serum sulfative and ANGPTL4 levels and AMI-HF patients'heart function indicators,and analyzes the value of serum sulfatide and ANGPTL4 levels in assessing the progress of AMI-HF disease.Results There was no significant difference in age,sex,heart rate,hypertension,diabetes,and smoking history between the two groups(P>0.05).Sulfatide,LVEDVI and LVESVI in the AMI-HF group were significantly higher than those in the AMI group,while ANGPTL4 and LVEF were lower than those in the AMI group,the difference was statistically significant(P<0.05).Logistic regression analysis found that sulfatide,ANGPTL4,LVEF,LVEDVI,and LVESVI were the influencing factors for heart failure in AMI patients(P<0.05).The correlation analysis of cardiac function indicators and serum sulfatide and ANGPTL4 in AMI-HF patients showed that serum sulfatide in AMI-HF patients was significantly negatively correlated with LVEF(P<0.05),and positively correlated with LVEDVI and LVESVI(P<0.05).ANGPTL4 was positively correlated with LVEF(P<0.05),and negatively correlated with LVEDVI and LVESVI(P<0.05).In AMI-HF patients,serum sulfatide in the good prognosis group was significantly lower than that in the poor prognosis group,and ANGPTL4 was higher than that in the poor prognosis group,with statistical significance(P<0.05).The combined value of serum sulfatide and ANGPTL4 in predicting the prognosis of AMI-HF is higher than that of single detection.Conclusion Monitoring serum sulfatide and ANGPTL4 levels in AMI-HF patients can provide objective evidence for disease progression.serum sulfatide and ANGPTL4 can also be an important indicators of prognosis of patients with AMI-HF.