CD68、TGF-β2及VEGF在良性前列腺增生中的水平变化及临床应用价值

Changes of CD68,TGF-β2 and VEGF levels in benign prostatic hyperplasia and their clinical value

目的分析巨噬细胞标志物(CD68)、转化生长因子标志物(TGF-β2)及血管内皮生长因子(VEGF)在良性前列腺增生中的水平变化及临床应用价值。方法选取2020年1月至2022年12月于重庆市永川区中医院进行治疗的良性前列腺增生患者207例(观察组)为研究对象,选取同期进行中老年男性健康体检者150名为对照组。对比两组血清CD68、TGF-β2、VEGF水平;对比观察组不同疾病程度BPH患者的CD68、TGF-β2、VEGF水平;采用Kappa一致性检验评估血清CD68、TGF-β2、VEGF单独以及联合诊断BPH与病理活检结果的一致性;绘制ROC曲线,分析血清CD68、TGF-β2、VEGF单独及联合诊断BPH的价值。结果对照组血清CD68、TGF-β2、VEGE水平均低于观察组,差异有统计学意义(P<0.05);观察组血清CD68、TGF-β2、VEGE水平:Ⅲ度>Ⅱ度>Ⅰ度,差异有统计学意义(P<0.05);血清CD68、TGF-β2、VEGF单独以及联合诊断BPH与病理活检结果的一致性Kappa值分别为0.536、0.617、0.631、0.878;血清CD68、TGF-β2、VEGF三者联合诊断BPH的AUC为0.812,高于三指标单独检测(P<0.05)。结论可通过检测血清CD68、TGF-β2、VEGF水平变化,了解BPH的发展情况,三指标有利于临床对患者进行早期诊断以及预后评估。

Objective To analyze the changes of cluster of differentiation 68(CD68),transforming growth factorβ2(TGF-β2)and vascular endothelial growth factor(VEGF)levels in benign prostatic hyperplasia(BPH)and preliminary clinical study.Methods 207 cases of benign prostatic hyperplasia patients(observation group)who were treated in our hospital from January 2020 to December 2022 were selected as the study objects,and 150 cases of middle-aged and elderly men who underwent healthy physical examination during the same period were selected as control group.The levels of serum CD68,TGF-β2,and VEGF were compared between the two groups;the levels of CD68,TGF-β2,and VEGF in patients with different degrees of BPH in the observation group were compared.The Kappa consistency test was used to evaluate the consis-tency of serum CD68,TGF-β2,VEGF alone or combined diagnosis of BPH and pathological biopsy results.The ROC curve was drawn to analyze the value of serum CD68,TGF-β2,and VEGF alone and in combination in diagnosing BPH.Results The levels of serum CD68,TGF-β2,and VEGE in the control group were lower than those in the observation group,and the difference was statistically significant(P<0.05).Serum CD68,TGF-β2,and VEGE levels in the observation group:GradeⅢ>GradeⅡ>GradeⅠ,and the difference was statistically significant(P<0.05).The Kappa values of serum CD68,TGF-β2,and VEGF alone and in combination for the diagnosis of BPH and pathological biopsy results were 0.536,0.617,0.631,and 0.878,respectively.The AUC of the combination of serum CD68,TGF-β2,and VEGF for the diagnosis of BPH was 0.812,which was higher than the three indicators are detected separately(P<0.05).Conclusion The development of BPH can be understood by detecting changes in serum CD68,TGF-β2,and VEGF levels.These three indicators are beneficial to clinical early diagnosis and prognosis assessment of patients.