H型高血压合并颈动脉粥样硬化患者红细胞分布宽度变化分析

Analysis of Red Blood Cell Distribution width in Patients with Type H Hypertension and Carotid Atherosclerosis

【目的】探讨合并颈动脉粥样硬化病变的H型高血压患者红细胞分布宽度(RDW)变化情况。【方法】前瞻性随机选择2019年5月至2020年12月本院收治的168例H型高血压患者,根据是否合并颈动脉粥样硬化将其分为观察组(合并颈动脉粥样硬化)和对照组(未合并颈动脉粥样硬化),每组84例。比较两组患者一般资料及RDW水平,比较不同RDW水平的H型高血压患者颈动脉粥样硬化情况,采用Pearson相关性分析RDW与临床指标的相关性。【结果】观察组患者高血压分级为3级比例、24 h动态收缩压(24hSBP)、RDW及同型半胱氨酸(Hcy)显著高于对照组,血红蛋白(Hb)低于对照组,差异有统计学意义(P<0.05)。高RDW亚组患者24hSBP、Hb及Hcy水平高于低RDW亚组,差异有统计学意义(P<0.05)。高RDW亚组颈动脉的斑块个数及粥样斑块面积以及颈动脉内中膜厚度(IMT)显著高于低RDW亚组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,RDW与24hSBP(r=0.419)、Hcy(r=0.327)、粥样斑块面积(r=0.506)及IMT(r=0.238)呈显著正相关(均P<0.05)。【结论】RDW是H型高血压患者颈动脉粥样硬化病变的影响因素,临床医师可根据患者RDW变化评估H型高血压患者颈动脉粥样硬化病变情况,及时调整治疗方案。

【Objective】To investigate the changes of red blood cell distribution width(RDW)in patients with type H hypertension complicated with carotid atherosclerosis.【Methods】A total of 168 patients with type H hypertension admitted to our hospital from May 2019 to December 2020 were prospectively selected and randomly divided into an observation group(with carotid atherosclerosis)and a control group(without carotid atherosclerosis)according to whether they had carotid atherosclerosis.There were 84 patients in each group.The general data and RDW levels of the two groups of patients were compared,and the carotid atherosclerosis in patients with type H hypertension with different RDW levels was compared.Pearson correlation analysis was used to analyze the correlation between RDW and clinical indicators.【Results】The proportion of patients in the observation group with hypertension grade 3,24-hour dynamic systolic blood pressure(24hSBP),RDW,and homocysteine(Hcy)were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The 24hSBP,hemoglobin(Hb),and Hcy levels in the high RDW subgroup were higher than those in the low RDW subgroup,and the differences were statistically significant(P<0.05).The number and area of carotid plaque and carotid intima-media thickness(IMT)in the high RDW subgroup were significantly higher than those in the low RDW subgroup(P<0.05).Pearson correlation analysis showed that RDW was positively correlated with 24hSBP(r=0.419),Hcy(r=0.327),atherosclerotic plaque area(r=0.506)and IMT(r=0.238)(all P<0.05).【Conclusion】RDW is the influencing factor of carotid atherosclerosis in patients with type H hypertension.Clinicians can evaluate the carotid atherosclerosis in patients with type H hypertension according to the changes of RDW.