功能性消化不良患者心理状态与肠道菌群失调、胃肠动力的相关性

A Study on the Correlation between Psychological State and Dysbiosis of Gut Microbiota and Gastrointestinal Motility in Patients with Functional Dyspepsia

【目的】探讨功能性消化不良(FD)患者心理状态与肠道菌群失调、胃肠动力的相关性。【方法】选择2020年5月至2021年4月本院收治的80例FD患者为研究对象,分别采用抑郁自评量表(SDS)、新鲜粪标本定量定性检测、小钡条X线胃排空检查评估患者的抑郁水平、乳酸杆菌、肠球菌、餐后6 h胃排空率,采用Pearson相关性分析FD患者心理状态与肠道菌群失调、胃肠动力的关系。【结果】FD患者SDS评分为(59.41±4.85)分、乳酸杆菌计数为(6.45±1.27)lgCFU/g、肠球菌计数为(7.41±1.04)lgCFU/g、餐后6 h胃排空率为(88.36±6.74)%。Pearson相关性分析显示,SDS评分与肠球菌计数呈正相关(r=0.594,P<0.05),与餐后6 h胃排空率呈负相关(r=-0.721,P<0.05),与乳酸杆菌计数呈负相关(r=-0.622,P<0.05);乳酸杆菌计数与餐后6 h胃排空率呈正相关(r=0.580,P<0.05),与肠球菌呈负相关(r=-0.491,P<0.05);肠球菌计数与餐后6 h胃排空率呈负相关(r=-0.784,P<0.05)。【结论】功能性消化患者存在抑郁不良心理,临床医师应制定积极合理的心理治疗方式来纠正患者的不良心理,有助于改善患者胃肠道功能,促进患者早日康复。

【Objective】To explore the correlation between the psychological state of patients with functional dyspepsia(FD)and the imbalance of gut microbiota and gastrointestinal motility.【Methods】Eighty FD patients admitted to our hospital from May 2020 to April 2021 were selected as the study subjects.Depression levels,Lactobacillius,Enterococcus,and 6-hour postprandial gastric emptying rate were evaluated using the Self Rating Depression Scale(SDS),quantitative and qualitative detection of fresh fecal specimens,and small barium X-ray gastric emptying test,respectively.Pearson correlation analysis was used to examine the relationship between psychological status,gut microbiota imbalance,and gastrointestinal motility in FD patients.【Results】The SDS score of FD patients was(59.41±4.85)points,the Lactobacillus count was(6.45±1.27)lgCFU/g,the Enterococcus count was(7.41±1.04)lgCFU/g,and the gastric emptying rate at 6 hours after meals was(88.36±6.74)%.Pearson correlation analysis showed that SDS score was positively correlated with Enterococcus count(r=0.594,P<0.05),negatively correlated with postprandial gastric emptying rate at 6 hours(r=-0.721,P<0.05),and negatively correlated with Lactobacillus count(r=-0.622,P<0.05);Lactobacillus count was positively correlated with postprandial gastric emptying rate at 6 hours(r=0.580,P<0.05),and negatively correlated with Enterococcus(r=-0.491,P<0.05).The count of Enterococcus was negatively correlated with the gastric emptying rate at 6 hours after meals(r=-0.784,P<0.05).【Conclusion】Patients with functional digestion have a negative psychological state of depression,and clinical physicians should develop positive and reasonable psychological treatment methods to correct the patient's negative psychology,which can help improve the patient's gastrointestinal function and promote early recovery.