酒精性肝病合并乙型肝炎病毒感染病例临床分析

Clinical Analysis of Alcoholic Liver Disease Complicated with Hepatitis B Virus Infection

目的分析酒精性肝病合并乙型肝炎病毒感染患者的临床资料。方法取2018年4月至2019年12月于我院收治的30例酒精性肝病合并乙型肝炎病毒感染患者为观察组,同期选择30例酒精性肝病患者为对照组。比较两组临床表现(乏力、腹胀、黄疸等)、预后情况(上消化道出血、肝性脑病、肝癌等)、肝功能指标。结果观察组在临床症状表现方面,乏力占63.33%、腹胀占53.33%、黄疸占80.00%;预后情况,发生上消化道出血46.67%、肝性脑病占23.33%、肝癌占16.67%,均明显高于对照组(均P<0.05)。观察组肝功能指标也均明显高于对照组(均P<0.05)。结论酒精性肝病合并乙型肝炎病毒感染患者相比单纯酒精性肝病患者临床表现较重,肝脏损伤较重,预后较差。

Objective To analyze the clinical data of alcoholic liver disease combined with hepatitis B virus infection.Methods Thirty patients with alcoholic liver disease combined with hepatitis B virus infection admitted to our hospital from April 2018 to December 2019 were taken as the observation group,and 30 patients with alcoholic liver disease were selected as the control group in the same period.Compare the clinical manifestations(fatigue,abdominal distension,jaundice,etc.),prognosis(upper gastrointestinal hemorrhage,hepatic encephalopathy,hepatocellular carcinoma,etc.),and liver function indexes of the two groups.Results In the observation group,in terms of clinical symptoms,fatigue accounted for 63.33%,abdominal distension accounted for 53.33%,and jaundice accounted for 80.00%;in terms of prognosis,upper gastrointestinal hemorrhage,hepatic encephalopathy,hepatic carcinoma and other liver cancers accounted for 46.67%,23.33%,and 16.67%respectively,all of which were significantly higher than those of the control group(all P<0.05).The liver function indexes of the observation group were also all significantly higher than those of the control group(all P<0.05).Conclusions Patients with alcoholic liver disease combined with hepatitis B virus infection had more severe clinical manifestations,heavier liver damage and poorer prognosis compared with patients with simple alcoholic liver disease.