健康饮食模式对CKD患者死亡率、ESKD和CVD发生率影响的meta分析

Meta analysis of effects of healthy eating patterns on mortality,ESKD and CVD incidence in patients with CKD

目的通过meta分析探讨健康饮食模式对慢性肾脏病(CKD)患者死亡率、终末期肾病(ESKD)发生率、心血管疾病(CVD)发生率的影响。方法计算机检索PubMed、Embase、Cochrane Library、中国知网、万方数据库及维普数据库中关于健康饮食模式对CKD患者死亡率与ESKD、CVD发生率影响的研究,检索时间为建库至2023年1月。由两名研究者独立筛选文献和提取资料,并进行文献质量评价。采用RevMan5.3软件对纳入的文献进行meta分析。结果本研究共纳入10篇文献,涉及27291例患者。结果显示,饮食评分高的患者与饮食评分低的患者在死亡率(HR=0.70,95%CI:0.57~0.87,Z=3.18,P=0.001)、ESKD发生率(HR=0.80,95%CI:0.71~0.91,Z=3.44,P<0.001)和CVD发生率(HR=0.77;95%CI:0.61~0.97,Z=2.21,P=0.003)方面比较均有差异。结论坚持健康饮食模式会降低CKD患者死亡率、ESKD发生率和CVD发生率。

Objective To investigate the impact of healthy eating patterns on the mortality rate and incidence rates of end-stage kidney disease(ESKD)and cardiovascular disease(CVD)in the patients with chronic kidney disease(CKD)by meta analysis.Methods The studies on the relationship between the dietary patterns on the mortality,and the incidence rates of ESKD and CVD in the patients with CKD were retrieved from PubMed,Embase,Cochrane Library,CNKI,Wanfang Database and VIP Database.The retrieval time was from the database establishment to January 2023.The two researchers independently screened the literatures,extracted the data and conducted the literature quality evaluation.The RevMan5.3 software was used for the meta-analysis of the included literatures.Results A total of 10 studies were included in this study,involving 27291 patients.The results showed that the mortality(HR=0.70,95%CI:0.57-0.87,Z=3.18,P=0.001)and the ESKD incidence rate(HR=0.80,95%CI:0.71-0.91,Z=3.44,P<0.001)and CVD incidence rate(HR=0.77;95%CI:0.61-0.97,Z=2.21,P=0.003)had statistical differences between the patients with high dietary score and the patients with low dietary score.Conclusion Persisting in the healthy dietary patterns could decrease the mortality rate,and incidence rates of ESKD and CVD in the patients with CKD.