Notch1/Jagged1信号通路在慢性心力衰竭免疫炎症相关发病机制中的研究进展

Research progress of Notch1/Jagged1 signaling pathway in related pathogenesis of chronic heart failure immune inflammation

心力衰竭是由各种原因造成心肌受损,心脏功能降低而不能满足机体代谢需要的临床综合征。炎症细胞因子在心力衰竭的发生、发展过程中发挥重要作用,Notch1/Jagged1信号通路与炎症细胞因子、炎症反应和免疫反应有关。该文主要讨论了Notch1/Jagged1信号通路通过调节免疫炎症参与慢性心力衰竭的发生及发展情况。

Heart failure is a clinical syndrome caused by various causes of myocardial damage and cardiac function decrease that cannot meet the body’s metabolic needs.The proinflammatory cytokines play an important role in the process of occurrence and development of heart failure.The Notch1/Jagged1 signaling pathway is related to the proinflammatory cytokines,inflammatory responses and immune responses.This paper discusses the involvement of the Notch1/Jagged1 signaling pathway in the development and development of chronic heart failure by modulating immune inflammation.