重构本草——栀子

Reconstruction of Chinese materia medica–cape jasmine fruit

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出栀子:功效主要为泻火除烦,清热利湿,凉血解毒,外用消肿止痛。症靶为心烦、黄疸。标靶为高血糖。现代药理发现栀子及其有效成分具有抗炎解热、保肝利胆、保护神经、降血糖、降血脂、镇痛等作用。栀子具有肝肾毒性,栀子苷是主要的肝毒性成分,临床中应避免长期大剂量服用,同时注意合理配伍。临床使用剂量为3~30 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索栀子用量与症靶、标靶的量效关系构建。

Through the investigation of ancient literature and the sorting of modern research achievements in traditional Chinese medicine,combined with the understanding and application experience of well-known experts and scholars in the clinical and pharmaceutical fields of traditional Chinese medicine,it is concluded that cape jasmine fruit mainly has the following characteristics:Its main effects involve clearingfire and removing annoyance,clearing heat and promoting diuresis,cooling blood and detoxifying,and relieving swelling and pain for external use.Its symptom targets include vexation and jaundice,while its biochemical indicator target is hyperglycaemia.Modern pharmacology has found that cape jasmine fruit and its active ingredients have the effects of anti-inflammation and antipyretics,protecting the liver and gallbladder,protecting nerves,lowering blood sugar,lowering blood lipid,and analgesics.It has hepatorenal toxicity,and gardenoside is the main hepatotoxic component,so its long-term high-dose administration should be avoided in clinical practice and attention should be paid to its reasonable compatibility with other medicines.Its clinical dosage range is 3-30g.When taken orally,it should be used according to different diseases or different stages of the same disease,and the dose-effect relationship between its dosage and symptom targets,biochemical indicator targets should be actively explored and reconstructed.