克感利咽口服液治疗流行性感冒(风热犯肺证)的临床疗效及对免疫功能指标的影响

Clinical efficacy of Kganliyan oral liquid in the treatment of influenza(windheat invading lung syndrome)and its influence on immune function indexes

目的探究与分析克感利咽口服液治疗流行性感冒(风热犯肺证)的临床疗效及对免疫功能指标的影响。方法采用随机数字表法对北京市门头沟区医院自2020年3月-2022年2月收治的流行性感冒(风热犯肺证)患者80例分组,每组各40例,对照组采用口服磷酸奥斯他韦颗粒治疗,观察组在对照组基础上增加克感利咽口服液治疗,对比两组疗效、风热犯肺证积分、主要症状消失时间、免疫功能指标变化。结果观察组与对照组相比,临床总有效率较高,退热时间、解热时间、咽痛消失时间、头身疼痛消失时间及咳嗽消失时间均较短,差异有统计学意义(P<0.05)。观察组治疗后与对照组比较,风热犯肺证积分较低,免疫功能指标中CD4^(+)较高、CD8^(+)较低、CD4^(+)/CD8^(+)较高,差异有统计学意义(P<0.05)。结论克感利咽口服液治疗流行性感冒(风热犯肺证)的疗效突出,症状消失时间缩短,同时还可促进调节免疫功能指标。

Objective To explore and analyze the clinical efficacy of Kganliyan oral liquid in the treatment of influenza(wind-heat invading lung syndrome)and its influence on immune function indexes.Methods A total of 80 patients with influenza(wind-heat invading lung syndrome)admitted to our hospital from March 2020 to February 2022 were divided into groups with 40 cases in each group.The control group was treated with oral oseltamivir phosphate granules,and the observation group was treated with Kganliyan oral liquid on the basis of the control group.The therapeutic effect,the score of wind-heat invading lung syndrome,the time for the main symptoms to disappear and the changes of immune function indexes were compared between the two groups.Results Compared with the control group,the total clinical effective rate of the observation group was higher,and the time of fever reduction,fever reduction,throat pain disappearance,head and body pain disappearance and cough disappearance were shorter,the difference was statistically significant(P<0.05).Compared with the control group after treatment,the score of wind-heat invading lung syndrome was lower in the observation group,and the indexes of immune function were higher in CD4^(+),lower in CD8^(+),and higher in CD4^(+)/CD8^(+),with statistical significance(P<0.05).Conclusion Kganliyan oral liquid is effective in treating influenza(wind-heat invading lung syndrome),shortening the time of symptom disappearance,and promoting the adjustment of immune function index.