克立硼罗软膏和他克莫司软膏对特应性皮炎患儿的疗效观察

Observation of therapeutic effects of Clenborough ointment and Tacrolimus ointment on children with atopic dermatitis

目的探讨克立硼罗软膏和他克莫司软膏对特应性皮炎(AD)患儿的临床疗效。方法将2022年6月—2023年5月在温州市中心医院治疗的126例AD患儿按照随机分配的原则分为对照组(63例)和观察组(63例)。两组患儿入院后均采取常规处理,对照组给予他克莫司软膏治疗,观察组给予克立硼罗软膏治疗。比较两组临床疗效、AD病情严重程度、AD积分指数(SCORAD)评分以及不良反应。结果观察组治疗总有效率(65.1%vs.44.4%)高于对照组(P<0.05)。治疗2周后,观察组患儿AD严重程度明显低于对照组(P<0.05)。治疗1周后、治疗2周后,两组患儿SCORAD评分均明显降低,且观察组患儿SCORAD评分低于对照组(P<0.05)。两组患儿不良反应总发生率(7.9%vs.11.1%)比较差异无统计学意义(P>0.05)。结论与他克莫司软膏相比,采用克立硼罗软膏治疗特应性皮炎患儿的效果更佳,更利于缓解患儿AD症状,且安全性良好。

Objective To explore the clinical efficacy of Crisaborole ointment and Tacrolimus ointment in the treatment of children with atopic dermatitis(AD).Methods 126 children with AD who were treated in Wenzhou Central Hospital from June 2022 to May 2023 were randomly divided into a control group(63 cases)and an observation group(63 cases).Both groups were treated with routine treatment after admission,and the control group was treated with Tacrolimus ointment,the observation group was treated with Crisaborole ointment.The clinical efficacy,severity of AD,SCORAD score and adverse reactions between the two groups were compared.Results The total effective rate of the observation group(65.1%us.44.4%)was higher than that of the control group(P<0.05).After 2 weeks of treatment,the severity of AD in the observation group was significantly lower than that in the control group(P<0.05).After 1 week and 2 weeks of treatment,the SCORAD scores of both groups of children were significantly reduced,and the SCORAD scores of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of children(7.9%us.11.1%),comparing differences with statistical significance(P>0.05).Conclusion Compared with Tacrolimus ointment,Crisaborole ointment is more effective in the treatment of children with atopic dermatitis,more conducive to alleviating the symploms of children with AD,and has goodl safety.