和胃降逆法联合甲地孕酮对结肠癌癌性疲乏患者食欲的影响

Effect of Hewei Jiangni Method Combined with Megestrol on Appetite in Patients with Colon Cancer Fatigue

目的探讨和胃降逆法联合甲地孕酮对结肠癌癌性疲乏患者食欲的影响。方法方便选择2020年5月—2023年2月山东省泰安市肿瘤防治院收治的结肠癌出现癌性疲乏患者84例为研究对象。按照随机数表法分为观察组和对照组,各42例。对照组口服甲地孕酮分散片,观察组则在对照组基础上,结合和胃降逆方进行干预,统计两组干预前后每日营养摄入类型总量,比较两组干预过程中营养风险筛查2002(Nutrition Risk Screening,NRS-2002)量表评分变化,比较两组干预1疗程后机体总蛋白水平、机体热量代谢指标及癌性疲乏量表各分项得分变化情况。结果干预后观察组摄入谷物类水平为(127.4±10.9)g,少于对照组,差异有统计学意义(t=6.109,P<0.05),蔬果类水平多于对照组,动物类水平少于对照组,差异有统计学意义(P<0.05);干预1周后和干预1疗程后,观察组NRS—2002量表评分为(4.3±0.3)分和(2.1±0.2)分,显著低于同期对照组,差异有统计学意义(t=13.476、39.212,P<0.05),干预1疗程后,观察组总蛋白水平为(65.9±7.5)g,高于对照组,差异有统计学意义(t=11.408,P<0.05),热量摄入量和尿素氮生成率均高于对照组,差异有统计学意义(P<0.05),干预1疗程后,观察组Piper癌性疲乏量表各分项如行为及严重程度、情感、感觉、认知及情绪得分均高于对照组,差异有统计学意义(P<0.05)。结论和胃降逆法干预结肠癌癌性疲乏患者食欲不振者,对改善患者食欲,确保机体营养供应有重要意义,在一定程度上还可改善癌性疲乏症状。

Objective To investigate the effect of Hewei Jiangni method combined with megestrol on appetite in patients with colon cancer fatigue.Methods A total of 84 patients with cancer fatigue of colon cancer treated in Tai'an Cancer Prevention and Control Hospital of Shandong Province from May 2020 to February 2023 were conveniently selected as the study objects.According to random number table method,they were divided into observation group and control group,with 42 cases in each.The control group was given megestrol dispersive tablets by mouth,and the observation group was combined with Hewei Jiangni method on the basis of the control group.The total types of daily nutrition intake before and after intervention were counted in the two groups,and the score changes of the Nutrition Risk Screening(NRS-2002)were compared between the two groups during the intervention.The changes of total protein level,caloric metabolism index and cancer fatigue scale scores were compared between the two groups.Results After intervention,the intake level of cereals in the observation group was(127.4±10.9)g,which was lower than that of the control group,and the difference was statistically significant(t=6.109,P<0.05),the intake level of fruits and vegetables was more than that of the control group,and the intake level of animals was lower than that of the control group,and the differences were statistically significant(P<0.05).After 1 week of intervention and 1 course of intervention,the scores of NRS-2002 in the observation group were(4.3±0.3)points and(2.1±0.2)points,which were significantly lower than those in the control group,and the differences were statistically significant(t=13.476,39.212,P<0.05).After 1 course of intervention,the total protein level of observation group was(65.9±7.5)g,which was higher than that of control group,and the difference was statistically significant(t=11.408,P<0.05),caloric intake and urea nitrogen production rate were higher than those of control group,and the differences were statistically significant(P<0.05).After 1 course of intervention,the Piper cancer fatigue scale scores,such as behavior and severity,emotion,sensation,cognition and emotion,were higher in the observation group than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The intervention of Hewei Jiangni method in patients with colon cancer induced fatigue and loss of appetite is of great significance in improving their appetite,ensuring the supply of nutrients to the body,and to some extent,can also improve the symptoms of cancer induced fatigue.