109种注射液的溶剂选择探讨

Selection of 109 Kinds of Solvents for Injection

目的探讨静脉药物调配中心(PIVAS)注射液溶剂的选择,以提高成品输液质量。方法收集华北医疗健康集团邢台总医院PIV⁃AS中调配的109种注射液的药品说明书,采用计算机检索中国知网(CNKI)、万方(WanFang)、PubMed等数据库中的相关文献,分析溶剂种类和用量对溶剂选择的影响。结果109种注射液中,36种注射液提及溶剂用量及范围,22种注射液限制了成品输液的浓度,56种注射液对溶剂种类有明确要求。其中,可以选择1种、2种、3种及以上溶剂的分别有28种、23种、5种。结论临床应慎重选择注射液的溶剂,保证成品输液稳定,减少不良反应,保障静脉用药的治疗效果。

Objective To investigate the selection of solvents for injection in the Pharmacy Intravenous Admixture Services(PIVAS),and to improve the quality of finished infusion products.Methods The drug instructions of 109 kinds of injections in the PIVAS from the North China Medical and Health Group Xingtai General Hospital were collected,and the relevant literature was searched from databases such as CNKI,WanFang,and PubMed to analyze the effects of kinds and dosages of the solvent on the selection of solvent.Results Among the 109 kinds of injections,36 kinds of injections mention solvent dosage and range,while 22 kinds of injections limit the concentration of finished infusion products;56 kinds of injections have clear requirements on the type of solvent,among which 28,23,and 5 kinds of injections are designated to choose one,two,three,or more solvents respectively.Conclusion In clinical practice,the solvent for injection should be carefully selected to ensure the stability of the finished infusion,reduce adverse drug reactions,and ensure the therapeutic effect of intravenous medication.