小胶质细胞在癫痫发作状态中的研究进展

Research advances in microglia in the seizure state

癫痫是一组由于脑部神经元异常过度放电引起的中枢神经系统疾病。小胶质细胞作为中枢神经系统的主要免疫细胞对神经的发育和维持起着重要作用。尽管研究报道,小胶质细胞可通过增加炎症介质等生物活性物质介导癫痫发作,但对于炎症介质相关的信号转导通路仍缺乏全面了解。此外,越来越多的证据证明,小胶质细胞在神经元变性、神经发生及突触修剪中发挥着至关重要的作用,这与癫痫的发生发展有关。因此,进一步研究小胶质细胞在癫痫发作过程中的生物学功能,明确小胶质细胞在癫痫中的分子机制,可为临床治疗癫痫提供新的分子靶点。

Epilepsy is a group of central nervous system diseases caused by abnormal excessive discharge of brain neurons.Microglia,as the main immune cells in the central nervous system,play an important role in the development and maintenance of nerves.Although studies have shown that microglia cells can mediate the development of epilepsy by increasing bioactive substances such as inflammatory mediators,there is still a lack of comprehensive understanding of the signal transduction pathways associated with such inflammatory mediators.Moreover,more and more evidence has proven that microglia play a crucial role in neuronal degeneration,neurogenesis,and synaptic pruning,which is associated with the development of epilepsy.Therefore,further studies on the biological function of microglia in the development of epilepsy and the molecular mechanism of microglia cells in epilepsy can provide new molecular targets for the clinical treatment of epilepsy.