晚发性癫痫的临床研究进展

Clinical research advances in late-onset epilepsy

晚发性癫痫(LOE)是指65岁以上老年人新发的癫痫。LOE的患病率及发病率逐年升高,但相关临床研究较少,这为LOE患者临床管理带来了挑战。该综述回顾了近10年关于LOE研究的文献,总结了LOE的定义、流行病学资料、病因、临床表现、诊断、鉴别诊断及治疗,希望为LOE患者的临床规范化管理提供参考。

Late-onset epilepsy(LOE)refers to newly diagnosed epilepsy in elderly people aged 65 years and above.The prevalence and incidence rates of LOE are increasing year by year.However,few clinical studies have investigated this condition,and the clinical management of patients with LOE faces challenges.This review presents the definition,epidemiological data,etiology,clinical manifestations,diagnosis,differential diagnosis,and treatment of LOE on the basis of literature on LOE in the recent decade.We hope to provide some guidance for standardized management of patients with LOE in clinical practice.