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B类1型清道夫受体在心血管疾病中的作用

Effects of SR-B1 on cardiovascular diseases
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摘要 B类1型清道夫受体(scavenger receptor class B type 1,SR-B1)是一种广泛表达于多种组织和细胞表面的膜蛋白受体,为清道夫受体家族的重要一员。SR-B1具备丰富的生物学活性,集中体现在胆固醇运转、炎症反应、免疫调节、氧化应激等多种病理生理过程中,在肝脏、巨噬细胞、内皮细胞、血小板等细胞组织含量丰富,以重要身份参与多种心血管疾病过程,如动脉粥样硬化、心肌梗死和糖尿病相关心血管并发症等。近来,SR-B1在该领域的研究已得到国内、外学者们广泛关注,也为心血管疾病的致病机理及诊治提供新思路。本文就SR-B1生物学功能及其在心血管疾病中的作用关系等进行简述。
作者 李许霞 徐明国 LI Xuxia;XU Mingguo
出处 《岭南心血管病杂志》 CAS 2023年第5期567-572,共6页 South China Journal of Cardiovascular Diseases
基金 国家自然科学基金面上项目(项目编号:81870364) 深圳市科创委科技计划项目(项目编号:JCYJ20190809164004023) 深圳市龙岗区医疗卫生科技计划项目(项目编号:LGKCYLWS2021000020)。
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