视雪综合征的研究进展

The Research Progress of Visual Snow Syndrome

视雪综合征(VSS)是一种以全视野中持续出现闪烁光点为临床特征的视觉障碍疾病,可伴畏光、夜盲等视觉症状和偏头痛、焦虑、抑郁等非视觉症状。VSS在病程中可保持稳定或持续恶化,对患者的视觉体验和精神状态带来极大痛苦。目前其病理机制尚不明确,有学说提示可能与视觉中枢皮层兴奋性增加相关。病例报道显示抗癫痫药、彩色滤光片、经颅磁刺激等治疗手段可能有助于改善症状,但仍需进一步临床研究验证。本文将对VSS的研究进展进行系统介绍。

Visual snow syndrome(VSS)is a visual-disturbance disease characterized by continuous flickering tiny dots in the entire visual field,sometimes with visual symptoms like photophobia or nyctalopia and non-visual symptoms such as anxiety and depression.VSS can remain stable or worsen,causing distress to patients′visual experience and mental state.The pathological mechanism of VSS is still unclear and a hy-pothesis indicates a relationship between VSS and increased cortical excitability of the visual cortex.Some case reports suggest anti-seizure medications,colored filters and TMS may help eliminate symptoms,but futh-er studies are required to verify these treatments.This review will systematically introduce what we know about VSS so far.