中医药调控程序性细胞死亡干预肝纤维化的研究进展

Research advances in traditional Chinese medicine regulation of programmed cell death in intervening against hepatic fibrosis

肝纤维化(HF)是一种由于慢性肝损伤导致的肝组织结构异常修复的病理过程,其发病机制尚未完全阐明。相关研究表明,程序性细胞死亡可能与HF的发生有关,而中医药在调控程序性细胞死亡干预HF方面有着显著疗效。本文概述了程序性细胞死亡影响HF的主要机制,并从中医角度出发探讨中医药调控程序性细胞死亡改善HF的可能机制,为中医药防治肝纤维化提供新思路。

Hepatic fibrosis(HF)is a pathological process of abnormal repair of liver tissue structure caused by chronic liver injury,and its pathogenesis has not been fully clarified.Related studies have shown that programmed cell death may be associated with the onset of HF,and traditional Chinese medicine(TCM)has a significant effect in regulating programmed cell death to intervene against HF.This article reviews the main mechanism of the influence of programmed cell death on HF and discusses the possible mechanism of TCM regulation of programmed cell death in improving HF,which provides new ideas for TCM prevention and treatment of HF.