半乳糖凝集素-9(Gal-9)介导的免疫调节作用在肝脏疾病中的研究进展

Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases

半乳糖凝集素-9(Gal-9)是能够特异性识别、结合半乳糖苷的半乳糖凝集素家族成员之一。近年研究发现,Gal-9在肝脏中高水平表达,有助于维持肝内免疫稳态并在多种肝脏疾病中发挥生物学功能。本文综述了Gal-9的免疫调节功能及其在不同肝脏疾病中的作用。Gal-9在不同肝脏疾病中通过多种途径发挥重要的生物学功能,基于对Gal-9具体免疫调节机制和功能的研究,有助于发现Gal-9在肝脏疾病中的治疗作用。

Galectin-9(Gal-9)is a member of the galectin family that can specifically recognize and bind to galactosides.Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases.This article reviews the immunomodulatory functions of Gal-9 and its role in different liver diseases.Studies have shown that Gal-9 has important biological functions in different liver diseases through multiple pathways.Research on the specific immunomodulatory mechanisms and functions of Gal-9 may help to discover the therapeutic role of Gal-9 in liver diseases.