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舒脉胶囊治疗早期糖尿病足神经性溃疡的临床疗效观察

Clinical evaluation of Shumai capsules in the treatment of early-stage diabetic foot neuropathic ulcers
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摘要 目的:探讨舒脉胶囊治疗糖尿病足神经性溃疡的临床应用价值。方法:选取2020年1月-2021年6月于首都医科大学附属北京中医医院收治的82例糖尿病足神经性溃疡患者。采用随机数字表法将82例患者随机分为观察组和对照组各41例。对照组采用常规西医治疗,观察组采用常规西医治疗联合舒脉胶囊治疗。比较两组的多伦多临床神经病变(TCSS)评分、相关炎症因子水平、正中神经、腓总神经运动传导速度(MNCV)、正中神经、腓总神经感觉传导速度(SNCV)、创面愈合情况。结果:治疗后,观察组TCSS评分优于对照组,差异有统计学意义(P <0.05);观察组胰岛素样生长因子1(IGF-1)、表皮细胞生长因子(EGF)、一氧化氮(NO)水平高于对照组,肿瘤坏死因子(TNF)-α水平低于对照组,差异有统计学意义(P <0.05);观察组干预后正中神经、腓总神经MNCV均高于同组干预前和对照组干预后,差异有统计学意义(P <0.05);观察组干预后正中神经、腓总神经SNCV水平均高于对照组干预后,差异有统计学意义(P <0.05)。观察组患者创面总愈合率高于对照组,差异有统计学意义(P <0.05)。结论:舒脉胶囊治疗早期糖尿病足神经性溃疡疗效确切,能够减轻患者神经病变症状,改善患者的炎症因子水平,提高神经传导速度,促进创面愈合,应用价值较高。 Objective To investigate the clinical value of Shumai capsules in treating neuropathic ulcers in diabetic foot.Methods 82 patients who visited the affiliated Beijing Traditional Chinese Medicine Hospital of Capital Medical University between January 2020 and June 2021 were included in this study.Using a random number table,samples were drawn and equally divided into an observation group and a control group,with 41 patients each.Control group:Standard western medical treatment.Observation group:Standard western medical treatment combined with Shumai capsule treatment.Observational indicators included:TCSS score,levels of related inflammatory factors,median nerve and peroneal nerve MNCV,median nerve and peroneal nerve SNCV,and wound healing status.Results The TCSS score of the observation group was better than that of the control group,showing a statistically significant difference(P<0.05).The levels of IGF-1,EGF,and NO in the observation group were higher than in the control group,while the level of TNF-α was lower(P<0.05).After intervention,the median and peroneal nerve MNCV levels in the observation group were higher than those before intervention within the same group and after intervention in the control group,with a significant difference(P<0.05).After intervention in the observation group,the median and peroneal nerve SNCV levels were higher than those after intervention in the control group,with a significant difference(P<0.05).The overall wound healing rate of the observation group was higher than that of the control group,with a statistically significant difference(P<0.05).Conclusion The Shumai capsule treatment for early-stage neuropathic diabetic foot ulcers is effective.It can alleviate symptoms of nerve lesions in patients,improve the level of inflammatory factors,enhance nerve conduction speed,promote wound healing,and holds high clinical value.
作者 李晓庆 谢书睿 黄天一 LI Xiao-qing;XIE Shu-rui;HUANG Tian-yi(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing(100010),China)
出处 《中国中西医结合外科杂志》 CAS 2024年第1期9-12,共4页 Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金 青年科学基金资助课题(82004120)。
关键词 舒脉胶囊 糖尿病足神经性溃疡 多伦多临床神经病变评分 炎症指标 创面愈合 Shumai capsules diabetic foot neuropathic ulcers TCSS score inflammatory factors wound healing
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