肠道菌群与炎症性肠病合并脊柱关节炎的研究进展

Progress of Research on Gut Flora and Inflammatory Bowel Disease Accompanied With Spondyloarthritis

炎症性肠病(IBD)是一种慢性非特异性肠道炎性疾病。脊柱关节炎(SpA)是一种发生于中轴骨骼和周围关节的慢性炎性疾病,是IBD最常见的肠外表现之一。IBD合并SpA的主要病理生理机制涉及“肠-关节轴”假说,菌群失调在解释IBD合并SpA患者“肠-关节轴”的病理联系时起到了关键性作用。本文就肠道菌群与IBD合并SpA的研究进展作一综述。

Inflammatory bowel disease(IBD)is a chronic non-specific intestinal inflammatory disease.Spondyloarthritis(SpA)is a chronic inflammatory disease that occurs in the axial skeleton and surrounding joints,and is one of the most common extraintestinal manifestations of IBD.The main pathophysiologic mechanism of IBD accompanied with SpA involves the"gut-joint axis"hypothesis,and dysbiosis of gut flora plays a key role in explaining the pathologic connection of the"gut-joint axis"in patients with IBD accompanied with SpA.This article reviewed the progress of research on gut flora and IBD accompanied with SpA.