摘要
干扰素诱导蛋白16(interferonγ-inducible protein 16,IFI16)是人类PYHIN(pyrin and HIN domain-containing protein)家族(也称干扰素诱导蛋白P200家族)成员之一,在人体器官组织中广泛存在,参与细胞周期调控、细胞衰老、细胞凋亡及免疫反应等多种生物过程。不同生理及病理状态下,IFI16的含量及定位均会发生改变,近年来研究发现,其在抗病毒、肿瘤、炎性疾病及其他多种疾病发生发展过程中可能发挥重要作用。该文对其机制及其在疾病中的研究现状进行综述,以期为深入研究IFI16提供参考。
Interferonγ-inducible protein 16(IFI16)is one member of human pyrin and HIN domain-containing protein(PYHIN)family(also known as interferon-inducible p200 protein family),which is widely present in human organs and tissues,and is involved in cell cycle regulation,senescence and apoptosis,even in immune reaction.The content and localization of IFI16 may change under different physiological and pathological conditions,and recent studies have revealed that it may play an important role in the development of antiviral,tumor,inflammatory diseases and other diseases.In this paper,we review its mechanism and the current status of its research in diseases,with the aim of providing a reference for the in-depth study of IFI16.
作者
崔京
李逸雯
刘艳飞
刘玥
CUI Jing;LI Yi-wen;LIU Yan-fei;LIU Yue(National Clinical Research Centre for Chinese Medicine Cardiology,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;Dept of Geriatric MedicineⅡ,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2024年第2期219-224,共6页
Chinese Pharmacological Bulletin
基金
中医药特色人才培养工程(岐黄工程)青年岐黄学者项目
国家自然科学基金优秀青年科学基金(No 82022076)。
关键词
干扰素诱导蛋白16
PYHIN
细胞衰老
生物学机制
疾病
进展
interferon-inducible protein 16
PYHIN
cell aging
biological mechanism
disease
research development