干扰素诱导蛋白16的生物学机制研究进展

Research progress on biological mechanism of interferon-inducible protein 16

干扰素诱导蛋白16(interferonγ-inducible protein 16,IFI16)是人类PYHIN(pyrin and HIN domain-containing protein)家族(也称干扰素诱导蛋白P200家族)成员之一,在人体器官组织中广泛存在,参与细胞周期调控、细胞衰老、细胞凋亡及免疫反应等多种生物过程。不同生理及病理状态下,IFI16的含量及定位均会发生改变,近年来研究发现,其在抗病毒、肿瘤、炎性疾病及其他多种疾病发生发展过程中可能发挥重要作用。该文对其机制及其在疾病中的研究现状进行综述,以期为深入研究IFI16提供参考。

Interferonγ-inducible protein 16(IFI16)is one member of human pyrin and HIN domain-containing protein(PYHIN)family(also known as interferon-inducible p200 protein family),which is widely present in human organs and tissues,and is involved in cell cycle regulation,senescence and apoptosis,even in immune reaction.The content and localization of IFI16 may change under different physiological and pathological conditions,and recent studies have revealed that it may play an important role in the development of antiviral,tumor,inflammatory diseases and other diseases.In this paper,we review its mechanism and the current status of its research in diseases,with the aim of providing a reference for the in-depth study of IFI16.