来曲唑联合HMG用药对PCOS并不孕症患者疗效及生殖内分泌激素、HGF水平的作用研究

Study on the efficacy and reproductive endocrine hormone and HGF levels of letrozole combined with HMG in patients with PCOS and infertility

目的 探讨来曲唑结合注射用尿促性素(HMG)用药对多囊卵巢综合征(PCOS)并不孕症患者疗效及生殖内分泌激素、肝细胞生长因子(HGF)水平的作用研究。方法 前瞻性选取2020年6月至2021年6月临沂市中心医院诊治的PCOS并不孕症患者103例作为本研究对象,以随机数表法将其分成观察组(n=52)和对照组(n=51),对照组予以来曲唑治疗,观察组在对照组基础上予以HMG用药治疗,比较两组的临床效果、妊娠率、诱发排卵相关指标、治疗前后雌激素及HGF水平,同时观察记录患者不良反应状况。结果 观察组的临床总有效率及妊娠率高于对照组,差异有统计学意义(P <0.05);观察组排卵率高于对照组,差异有统计学意义(P <0.05),诱发排卵时间显著短于对照组,差异有统计学意义(P <0.05);治疗后两组患者雌激素与HCF水平较治疗前明显改善,差异有统计学意义(P <0.05),且观察组血清雌二醇(E2)水平较对照组高,差异有统计学意义(P <0.05),黄体生成素(LH)、HGF水平较对照组低,差异有统计学意义(P <0.05);应用来曲唑结合HMG用药治疗的观察组出现呕吐、卵巢过度刺激综合征及水肿等不良反应总发生率较对照组低,差异无统计学意义(P> 0.05)。结论 应用来曲唑联合HMG用药治疗PCOS并不孕症患者效果显著,可有效促进排卵水平,改善雌激素水平及细胞生长因子,缓解不良症状,副作用小,安全性好,值得临床深入推广。

Objective To investigate the therapeutic effect of letrozole combined with Urotropin for injection(HMG)on patients with polycystic ovary syndrome(PCOS)and infertility,as well as the effects of reproductive endocrine hormones and hepatocyte growth factor(HGF)levels.Methods A total of 103 patients with PCOS and infertility who were diagnosed and treated in Linyi Central Hospital from June 2020 to June 2021 were prospectively selected as the subjects of this study.They were divided into an observation group(n=52)and a control group(n=51)by using the number table method.The control group was treated with letrozole,while the observation group was treated with HMG based on letrozole.The clinical efficacy,pregnancy rate,ovulation induction-related indicators,estrogen levels before and after treatment,and HGF levels were compared between the two groups.At the same time,the adverse reactions of the patients were observed and recorded.Results The clinical effective rate and pregnancy rate of the observation group were higher than those of the control group,with statistically significant differences(P<0.05).The ovulation rate in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The induction time of ovulation was significantly shorter than that in the control group,with statistically significant difference(P<0.05).After treatment,the levels of estrogen and HCF in the two groups were significantly improved compared with those before treatment,with statistically significant differences(P<0.05).The serum estrogen(E2)levels in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).The levels of luteinizing hormone (LH) and HGF in the observation group were lower than those in the control group, with statistically significant differences (P < 0.05). The total incidence of adverse reactions such as vomiting, ovarian hyperstimulation syndrome, and edema in the observation group treated with letrozole combined with HMG was lower than that in the control group, with no statistically significant difference (P > 0.05). Conclusion The application of letrozole combined with HMG in the treatment of PCOS patients with infertility has a significant effect, which can effectively promote ovulation levels, improve estrogen levels and cell growth factors, alleviate adverse symptoms, and reduce side effects, with good safety. Therefore, it is worthy of promotion in clinical practice.