广西全州县癫痫共患抑郁症现状及其影响因素分析

Present situation and influencing factors of Depression in Patients with Epilepsy in Quanzhou County,Guangxi

目的调查广西桂林市全州县癫痫共患抑郁症的情况及其影响因素,提高基层对癫痫共患抑郁症的重视,为维护癫痫患者的心理健康提供依据。方法通过问卷调查的方式收集广西桂林市全州县已经过初筛及神经科医师复核入组的癫痫患者的姓名、性别、年龄等基本情况;通过中文版NDDI-E量表评估癫痫患者共患抑郁症的情况;对可能影响癫痫患者共患抑郁症的因素进行分析,将单因素分析中有意义的变量进行多重logistic回归分析。结果本研究共纳入480例癫痫患者,癫痫共患抑郁者168例(35.0%)。单因素分析中,近一年发作次数(P=0.048)、是否接受过抗癫痫药物(AED)治疗(P=0.024)、是否罹患焦虑(P<0.001)和偏头痛(P<0.001)对癫痫患者是否共患抑郁有影响,差异具有统计学意义。二元logistic回归分析结果表明,近一年发作次数(OR=1.008,P=0.015)越多越容易共患抑郁,焦虑(OR=33.601,P<0.001)和偏头痛(OR=3.804,P<0.001)是影响癫痫患者共患抑郁症的危险因素。结论广西桂林市全州县癫痫共患抑郁症的患病率为35.0%,其危险因素包括近一年发作次数及共患焦虑和偏头痛。

Objective To investigate the prevalence and explore the influencing factors of depression in epilepsy patients in Quanzhou County,Guilin City,Guangxi Province,aiming to raise awareness of depression comorbidity with epilepsy at the grassroots level and provide reference for maintaining the psychological health.Methods A questionnaire survey was conducted among epilepsy patients in Quanzhou County,who have undergone initial screening and neurologist review.Basic information,such as the name,gender and age was collected.The Chinese version of the NDDI-E scale was used to assess the depression in epilepsy patients.Factors that may influence the depression in epilepsy patients were analyzed,and meaningful variables in the univariate analysis were included in the multiple logistic regression analysis.Results A total of 480 epilepsy patients were included in this study,with 168 cases(35.0%)having depression.In the univariate analysis,the frequency of seizures in the past year(P=0.048),whether or not they received treatment with antiepileptic drugs(AED)(P=0.024),comorbid anxiety(P<0.001)and migraine(P<0.001)had an impact on the occurrence of comorbid depression in epilepsy patients and the differences were statistically significant.The results of binary logistic regression analysis showed that the higher the frequency of seizures in the past year(OR=1.008,P=0.015)the epilepsy patients suffered,the more likely they had comorbid depression.Anxiety(OR=33.601,P<0.001)and migraine(OR=3.804,P<0.001)were risk factors for comorbid depression in epilepsy patients.Conclusion The prevalence of comorbid depression in epilepsy in Quanzhou County is 35.0%,and the risk factors influencing comorbid depression in epilepsy include the frequency of seizures in the past year,comorbid anxiety and migraine.