透明质酸钠凝胶预防宫腔镜子宫内膜息肉切除术后宫腔粘连的应用效果

Application effect of sodium hyaluronate gel in prevention of intrauterine adhesion after transcervical resection of polyp

目的 探讨透明质酸钠凝胶预防宫腔镜子宫内膜息肉切除术(TCRP)后宫腔粘连(IUA)的应用效果。方法 选取2021年3月至2022年2月上饶市广丰区人民医院收治的72例子宫内膜息肉(EPs)患者,按随机数字表法分为对照组(36例)与观察组(36例)。两组患者均行TCRP治疗,对照组术后采用常规抗感染治疗,观察组术后在对照组的方法基础上采用透明质酸钠凝胶膜贴治疗。比较两组患者的临床疗效、IUA评分、子宫内膜厚度、生活质量及并发症发生率。结果 观察组患者的治疗总有效率(RR)及子宫内膜厚度、健康调查简表(SF-36)评分高于对照组,IUA严重程度轻于对照组,IUA发生率及治疗后的IUA评分低于对照组,并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论 透明质酸钠凝胶膜贴可预防TCRP术后IUA的发生,可降低IUA发生率及并发症,促进子宫内膜修复,使患者生活质量获得改善,可作为预防TCRP术后IUA的一种安全、有效方法。

Objective To investigate the application effect of sodium hyaluronate gel in prevention of intrauterine adhesion(IUA) after transcervical resection of polyp(TCRP).Methods A total of 72 patients with endometrial polyps(EPs) admitted to the People's Hospital of Guangfeng District of Shangrao from March 2021 to February 2022 were selected as research objects,and they were divided into control group(36 cases) and observation group(36 cases) according to the random number table method.Both groups were treated with TCRP.The control group was treated with routine anti-infection treatment after operation,and the observation group was treated with sodium hyaluronate gel membrane on the basis of the control group.The clinical efficacy,IUA score,endometrial thickness,quality of life and incidence of complications were compared between the two groups.Results The total response rate(RR),endometrial thickness,and the MOS item short form health survey(SF-36) score of the observation group were higher than those of the control group,the severity of IUA was lighter than that of the control group,the incidence of IUA and IUA score after treatment were lower than those of the control group,and the total incidence of complications was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Sodium hyaluronate gel membrane can prevent the occurrence of IUA after TCRP,reduce the incidence and complications of IUA,promote endometrial repair,and improve the quality of life of patients.It can be used as a safe and effective method to prevent IUA after TCRP.