1-磷酸鞘氨醇在肾脏疾病中的作用研究进展

Research progress on the role of sphingosine-1-phosphate in kidney diseases

鞘脂及鞘脂代谢产物是一类重要的生物活性脂质,参与细胞生长、凋亡等多种生理病理过程的信号转导。鞘脂及鞘脂代谢产物在多种肾脏疾病中的表达变化,提示其可能参与了肾脏疾病的发生与发展。1-磷酸鞘氨醇是一种重要的生物活性鞘脂类代谢物,可参与急性肾损伤、糖尿病肾病、狼疮肾炎等的病理生理过程。探讨1-磷酸鞘氨醇代谢及其信号通路的调控,有可能为肾脏疾病治疗提供新思路。

Sphingolipids and sphingolipid metabolites are an important class of bioactive lipids,which are involved in signal transduction of various physiological and pathological processes such as cell growth and apoptosis.The expression changes of sphingolipids and sphingolipid metabolites in a variety of kidney diseases suggested that they may be involved in the development and progression of kidney diseases.Sphingosine-1-phosphate is an important bioactive sphingolipid metabolite,and can participate in the pathophysiological processes of acute kidney injury,diabetic kidney disease,and lupus nephritis,etc.Exploration of the regulation of sphingosine-1-phosphate metabolism and its signaling pathway may provide new ideas for the treatment of kidney diseases.