新型冠状病毒感染后认知功能障碍的研究现状

Research status of cognitive dysfunction after SARS-CoV-2 infection

目的对新型冠状病毒(SARS-CoV-2)与认知功能障碍的关系及新冠后遗症中认知功能障碍的发生机制进行综述。方法检索中国知网和PubMed数据库,收集2020年1月1日至2023年10月30日中医、西医关于SARSCoV-2感染后认知功能障碍的相关报道。结果SARS-CoV-2感染后可能会出现认知功能障碍,这可能与SARSCoV-2病毒具有神经侵袭性、嗜神经性、神经毒力有关,或与感染后介导的过度炎症反应、血清素水平及病毒转移等因素有关;并发现部分中药单体具有改善SARS-CoV-2感染后认知功能障碍的作用。结论SARS-CoV-2感染后可能会出现短时间或长期的认知功能障碍,其具体机制有待临床和基础研究的进一步验证,中药在改善此症状中具有较好的研究潜力。

Objective To review the relationship between severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and cognitive dysfunction and the mechanism of cognitive dysfunction in post-COVID-19 syndrome.Methods CNKI and PubMed databases were searched to collect relevant research reports on cognitive dysfunction after SARS-CoV-2 infection by traditional Chinese medicine(TCM)and western medicine from January 1,2020 to October 30,2023.Results Cognitive dysfunction might occur after SARS-CoV-2 infection,which might be related to the neuroaggressive,neurotropic,and neurovirulent nature of the SARS-CoV-2 virus,or to factors such as post-infection-mediated hyperinflammation,serotonin levels,and viral metastasis.It was also found that some TCM monomers had the effect of improving cognitive dysfunction after SARS-CoV-2 infection.Conclusion Cognitive dysfunction may occur for a short time or for a long time after SARSCoV-2 infection,and its mechanism needs to be further verified by clinical and basic research.