急性缺血性脑卒中患者血清s-100β、SCUBE1及cTnI水平变化与其病情严重程度的相关性

Correlation between the changes of serum s-100β,SCUBE1 and cTnI levels in patients with acute ischemic stroke and their severity

目的 探讨急性缺血性脑卒中(acute ischemic stroke, AIS)患者血清s-100β、SCUBE1及cTnI水平变化与其病情严重程度的相关性。方法 纳入2022年5月至2023年5月期间本院收治的80例AIS患者作为病例组,另选取80例同期行健康体检者作为对照组,分别检测两组患者的血清s-100β、SCUBE1及cTnI水平。根据美国国立卫生院卒中量表(NIHSS)评分将病例组患者分为轻型组(0~15分)、中型组(16~30分)及重型组(31~45),采用Pearson相关性分析法和logstic回归分析法分析血清因子与其病情严重程度的相关性,并利用受试者工作曲线(ROC)分析血清SCUBE1、s-100β及cTnI的诊断价值。结果 病例组血清cTnI、SCUBE1及s-100β水平均明显高于对照组(P<0.05)。重型组血清SCUBE1、s-100β和cTnI水平高于轻型组和中型组(均P<0.05)。相关性分析结果显示,脑卒中患者的血清cTnI、SCUBE1和s-100β水平均与NIHSS评分均呈正相关(r=0.436,0.393,0.502,P<0.05)。Logstic回归分析,结果显示,血清SCUBE1、cTnI及s-100β水平均是影响急性缺血性脑卒中患者病情严重程度的危险因素(P<0.05)。ROC曲线分析结果显示,血清SCUBE1、s-100β及cTnI水平预测脑卒中患者病情严重程度的AUC分别为0.784(0.680~0.889)、0.749(0.634~0.864)和0.727(0.608~0.847),其灵敏度分别为81.25%、78.13%及71.88%;特异度依次为62.41%、65.08%和67.53%。结论 血清s-100β、SCUBE1及cTnI水平均与AIS患者病情的严重程度存在密切联系,可为临床评估AIS患者的病情进展情况提供参考。

Objective To study the correlation between the changes of serum s-100β,SCUBE1,and cTnI levels and the severity of acute ischemic stroke(AIS).Methods Eighty AIS patients admitted to our hospital from May 2022 to May 2023 were included as the case group,and eighty healthy people in the same period were selected as the control group.The serum s-100β,SCUBE1,and cTnI levels of the two groups were detected respectively.Patients in the case group were divided into mild group(0~15 points),medium group(16~30 points),and severe group(31~45 points)according to the NIHSS score.Pearson correlation analysis and logistic regression analysis were used to analyze the correlation between serum factors and the severity of the disease,and the receiver's work curve(ROC)was used to analyze the serum SCUBE1,s-100βand cTnI.Results The levels of serum cTnI,SCUBE1,and s-100βin the case group were higher than those in the control group(P<0.05),and the levels of heavy serum SCUBE1,s-100β,and cTnI were better than those in the light and moderate groups(P<0.05).The correlation analysis results showed that the serum levels of cTnI,SCUBE1,and s-100βin stroke patients were positively correlated with NIHSS scores(r=0.436,0.393,0.502,P<0.05).The ROC curve analysis results show that the AUCs(area under the receiver operating characteristic curve)of serum SCUBE1,s-100β,and cTnI levels for predicting the severity of cerebral stroke were 0.784(0.680~0.889),0.749(0.634~0.864),and 0.727(0.608~0.847),respectively.The sensitivity of these three indicators are 81.25%,78.13%,and 71.88%,respectively,and the specificity order is 62.41%,65.08%,and 67.53%respectively.Conclusion Serum levels of s-100β,SCUBE1,and cTnI are closely related to the severity of AIS patients,which can be used to evaluate the progress of AIS patients.