中国中老年高血压患者并发认知障碍危险因素的Meta分析

Meta-analysis of risk factors for cognitive impairment in middle-aged and elderly Chinese hypertensive patients

目的 通过Meta分析系统评价中国中老年高血压患者并发认知障碍的危险因素。方法 检索PubMed、Cochrane Library、Embase、Web of Science、中国知网、维普、万方和中国生物医学文献数据库关于中国中老年高血压患者并发认知障碍危险因素的文献,检索时限为建库至2023年5月24日,采用Stata 17.0软件进行Meta分析。结果 共纳入24篇文献,包含5 177例中老年高血压患者。Meta分析结果显示:高龄、受教育程度低、吸烟、合并糖尿病、高血压2级、高血压3级、糖化血红蛋白升高、血清同型半胱氨酸升高、高血压病程长、24 h尿蛋白排泄率升高、血清25-羟维生素D水平降低及睡眠障碍是中老年高血压患者并发认知障碍的危险因素(P<0.05)。结论 中老年高血压患者认知障碍的发生受多种因素影响,医护人员应重点评估和管理高危人群,尽早干预,减少认知障碍的发生。

Objective To systematically evaluate the risk factors for cognitive impairment in middle-aged and elderly hypertensive patients in China.Methods The risk factors for cognitive impairment in middle-aged and elderly hypertensive patients in China were searched by PubMed,Cochrane Library,Embase,Web of Science,CNKI,VIP,Wan Fang,and CBM databases.The search time limit was from the establishment of the databases to May 24,2023.Stata 17.0 software was used for a meta-analysis.Results A total of 24 articles including 5177 middle-aged and elderly hypertensive patients.Meta-analysis showed that advanced age,low education,smoking,diabetes,hypertension stage 2,hypertension stage 3,increased HbA1c,increased Hcy,prolonged course of hypertension,increased 24-hour urinary protein excretion rate,reduced 25(OH)D and somnipathy were risk factors for comorbid cognitive impairment in middle-aged and elderly hypertensive patients.Conclusion The occurrence of cognitive impairment in middle-aged and elderly hypertensive patients is influenced by multiple factors.Medical staff should focus on evaluating and managing high-risk groups,intervene as soon as possible,and reduce the occurrence of cognitive impairment.