针对连续暴露因素的广义倾向评分方法在环境健康领域中的应用

Application of generalized propensity score for addressing continuous exposure in environmental health

目的介绍针对连续暴露因素的广义倾向评分(GPS)方法原理,探索其在环境健康领域中的应用,为测量环境健康风险提供有效工具。方法利用北京市“空气污染与人群健康队列研究”基线调查数据(2017—2018年),评价针对连续暴露因素的GPS方法在大气污染对健康效应估计中的应用效果。结果应用针对连续暴露水平的GPS方法后,不同暴露水平人群的混杂因素均衡性得到明显改善。PM_(2.5)暴露每增加10μg/m^(3),高血压患病的风险增加比例从原来的10.3%上升到11.9%。结论针对连续暴露水平的GPS方法在一定程度上为大气污染与健康的关联研究提供更准确的流行病学证据。

Objective To introduce the method of generalized propensity score(GPS)with continuous exposures,explore its ap-plication in the field of environmental health,and provide an effective tool for measuring environmental health risks.Methods The baseline investigation data from Beijing Air Pollution and Population Health Cohort Study(2017—2018)were performed to evaluate the application effect of GPS with continuous exposures in estimating the health effect of air pollution.Results After the application of GPS with continuous exposures,there was a significant improvement in balancing of confounding factors in populations with different exposure levels.For every 10μg/m^(3) increase of PM_(2.5) exposure,the risk of hypertension increased from 10.3%to 11.9%.Conclu-sion To a certain extent,GPS method with continuous exposures provides more accurate epidemiological evidence for studies on the association between air pollution and health.