ncRNA调控细胞程序性死亡影响动脉粥样硬化的研究进展

Advances in ncRNA regulation of programmed cell death affecting atherosclerosis

动脉粥样硬化(As)是许多心血管疾病(CVD)的发病基础,巨噬细胞、平滑肌细胞和内皮细胞是参与As病变的主要细胞,诸多研究证实上述细胞程序性死亡(PCD)可影响As的发生发展,调控上述PCD可能成为防治As的关键。近年来许多研究发现非编码RNA(ncRNA)通过调控相关因子参与PCD,如凋亡、自噬、焦亡、坏死性凋亡、铁死亡和铜死亡等。该文对ncRNA通过调控PCD影响As的机制展开讨论,为As的治疗提供新思路。

Atherosclerosis(As)is the basis of many cardiovascular diseases(CVD).Macrophage,smooth muscle cell and endothelial cell are the main cell involved in As lesions,and many studies have confirmed that the programmed cell death(PCD)of these cells can affect the development of As,and the regulation of the PCD of these cells may become the key to prevent and control As.In recent years,many studies have found that non-coding RNA(ncRNA)is involved in PCD by regulating related factors,such as apoptosis,autophagy,pyroptosis,necroptosis,ferroptosis and cuproptosis.This article discusses the mechanisms by which ncRNA affect As by regulating PCD and provides new ideas for As treatment.