巨噬细胞对动脉壁淋巴管生成的调节作用

Regulation of lymphangiogenesis in the arterial wall by macrophages

巨噬细胞在动脉粥样硬化中发挥多重作用。动脉粥样硬化的进展与病变部位动脉的淋巴管的形态和功能改变有关,但其机制尚不完全清楚。文章主要对动脉粥样硬化中巨噬细胞的来源、分型、标志物及对动脉粥样硬化的功能作用,淋巴管的起源、结构功能及标志物,动脉粥样硬化病变不同时期动脉壁淋巴管生成的变化,淋巴管生成在动脉粥样硬化中的功能作用,巨噬细胞的淋巴管迁移及其参与淋巴管新生的作用机制进行综述,以期为动脉粥样硬化的机制研究和临床治疗提供依据。

Macrophages play multiple roles in atherosclerosis.The progression of atherosclerosis is associated with morphological and functional changes in the lymphatic vessels of the diseased arteries,but the mechanism is not fully understood.This paper mainly reviews the origin and classification,the markers and the function of macrophage in atherosclerosis,the origin,the structure function and the markers of lymphatic vessels in atherosclerosis,the changes of arterial wall lymphangiogenesis in different stages of atherosclerotic lesions,the functional role of lymphangiogenesis in atherosclerosis,the lymphatic migration of macrophages and its mechanism involved in lymphangiogenesis,in order to provide a basis for the mechanism research and clinical treatment of atherosclerosis.