戊酸雌二醇联合乳酸菌阴道胶囊对老年性阴道炎的治疗效果及患者乳酸菌阳性率和生活质量的影响

Clinical effects of estradiol valerate combined with Lacidophilin vaginal capsules in senile vaginitis and its effects on the positive rate of lactic acid bacteria and life quality

目的:探究乳酸菌阴道胶囊治疗的基础上加用戊酸雌二醇治疗老年性阴道炎的效果,分析对患者乳酸菌阳性率和生活质量的影响。方法:选取2019年5月至2022年3月期间,我院收治的老年性阴道炎患者92例,随机分为单一组、联合组,各46例。单一组实施单一乳酸菌阴道胶囊治疗,联合组实施乳酸菌阴道胶囊+戊酸雌二醇治疗。比较两组治疗效果,治疗前后乳酸菌阳性率、阴道分泌物中白细胞介素-8(Interleukin-8,IL-8)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平、生活质量评分。结果:联合组临床效果、乳酸菌阳性率明显高于单一组;联合组治疗后阴道分泌物IL-8、IL-6、TNF-α水平较单一组均降低;联合组治疗后各生活质量评分均高于单一组(P<0.05)。结论:乳酸菌阴道胶囊的基础上加用戊酸雌二醇治疗老年性阴道炎可提高临床效果,提高乳酸菌阳性率,降低炎症反应,提高生活质量,可进一步临床推广。

Objective:To explore the clinical effects of estradiol valerate combined with Lacidophilin vaginal capsules in the treatment of senile vaginitis,and analyze the effects on the positive rate of lactic acid bacteria and the life quality of patients.Methods:From May 2019 to March 2022,92 patients with senile vaginitis admitted to our hospital were selected and divided into single group and combined group randomly,with 46 cases in each group.The single group was treated with Lacidophilin vaginal capsules,and the combination group was treated with Lacidophilin vaginal capsules+estradiol valerate.The clinical effect,the positive rate of lactic acid bacteria before and after treatment,the levels of interleukin-8(IL-8),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)in vaginal secretions,life quality score were compared between the two groups.Results:After treatment,the clinical effects and positive rate of lactic acid bacteria in the combined group were higher than those in the single group;the levels of IL-8,IL-6,and TNF-αin vaginal secretions in the combination group were lower than those in the single group;the life quality scores in the combined group were increased compared with those in the single group(all P>0.05).Conclusion:Adding estradiol valerate on the basis of Lacidophilin vaginal capsules to the treatment of senile vaginitis can improve the clinical effect,increase the positive rate of lactic acid bacteria,reduce the inflammatory response,and improve the life quality,worthy of clinical application.