西藏那曲市藏族人群高尿酸血症影响因素分析

Analysis of Influencing Factors of Hyperuricemia in Tibetan Population in Nagqu City,Tibet

目的分析西藏那曲市藏族人群高尿酸血症(hyperuricemia,HUA)的患病情况,并揭示其影响因素。方法2020年7月–2021年8月,采用多阶段整群随机抽样方法,对那曲市班戈县(新吉乡、佳琼镇)和色尼区(色雄乡)3个乡镇的763名世居藏族居民进行调查,采用回顾性分析方法研究HUA的患病情况,通过卡方检验、多因素logistic回归分析HUA患病率的影响因素。结果那曲市3个乡镇藏族人群HUA的总体患病率为19.66%(150/763),其中男性为35.00%,女性为8.58%,差异有统计学意义(P<0.05)。单因素分析显示:性别、肝功能异常、血红蛋白异常、高脂血症、低密度脂蛋白胆固醇偏高、高甘油三酯血症、高胆固醇血症、血肌酐异常、高同型半胱氨酸血症、肥胖程度、高血压在HUA与非HUA患者间的分布差异有统计学意义(P<0.05)。多因素logistic回归分析:女性性别〔比值比(odds ratio,OR)=0.195,95%置信区间(confidence interval,CI):0.120~0.315〕是HUA发病的保护因素,肝功能异常(OR=2.812,95%CI:1.685~4.692)、肌酐异常(OR=7.374,95%CI:1.446~37.620)、低密度脂蛋白胆固醇偏高(OR=2.357,95%CI:1.011~5.492)和高脂血症(OR=3.056,95%CI:1.886~4.951)为独立危险因素。结论那曲市HUA患病率较高,男性患病率远高于女性。男性、肝功能异常、肌酐异常、低密度脂蛋白胆固醇偏高和高脂血症可能为该地区人群发生HUA的危险因素。

Objective To analyze the prevalence of hyperuricemia(HUA)among the Tibetan population in Nagqu City,Tibet and to uncover the relevant influencing factors.Methods From July 2020 to August 2021,763 Tibetan natives from Bangor County(specifically Xinji Township and Jiaqiong Township)and Seni District(specificially Sexiong Township),Nagqu City were investigated by multi-stage cluster random sampling method and the prevalence of HUA was studied by retrospective analysis.Chi-square test and multiple logistic regression were used to analyze the influencing factors of HUA prevalence.Results The overall prevalence of HUA among the Tibetan population in the three townships of Nagqu City was 19.66%(150/763).In particular,the prevalence in men was 35.00%,while that in women was 8.58%,showing significant difference(P<0.05).According to the results of univariate analysis,there were significant differences in the distribution of sex,abnormal liver function,abnormal hemoglobin,hyperlipidemia,high level of lowdensity lipoprotein,hypertriglyceridemia,hypercholesterolemia,abnormal creatinine,hyperhomocysteinemia,obesity,and hypertension between HUA and non-HUA patients(P<0.05).Multiple logistic regression showed that female sex(odds ratio[OR]=0.195,95%confidence interval[CI]:0.120-0.315)was a protective factor for HUA,while abnormal liver function(OR=2.812,95%CI:1.685-4.692),abnormal creatinine(OR=7.374,95%CI:1.446-37.620),high level of lowdensity lipoprotein(OR=2.357,95%CI:1.011-5.492),and hyperlipidemia(OR=3.056,95%CI:1.886-4.951)were independent risk factors.Conclusion The prevalence of HUA is relatively high in Nagqu city and the prevalence of HUA is much higher in men than that in women.Male sex,abnormal liver function,abnormal creatinine,elevated lowdensity lipoprotein,and hyperlipidemia may be the risk factors for HUA in the local Tibetan population.