甲状腺结节发生与糖脂代谢水平的相关性分析

Analysis of the Correlation Between the Occurrence of Thyroid Nodules and the Level of Glucose and Lipid Metabolism

目的分析甲状腺结节发生与糖脂代谢水平的相关性。方法选取厦门弘爱医院(2022年1—12月)接受甲状腺检查者100例,根据患者的检查结果不同分组,其中检查结果为甲状腺结节的患者50例为研究组,检查结果为未发生甲状腺结节的患者50例为对照组。分析患者的基础资料,明确甲状腺结节发生与糖脂代谢水平[空腹血糖(fasting plasma glucose,FPG)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)及高密度脂蛋白胆固醇(high density lipid-cholesterol,HDL-C)]的相关性。结果研究组FPG、TC、TG和LDL-C水平较对照组更高,差异有统计学意义(P<0.05)。而在HDL-C指标相比之下,差异无统计学意义(P>0.05)。因FT3、FT4、TSH均有不确定值为等级资料行Spearman秩相关分析。TSH与FPG、TC、LDL-C、HDL-C均呈正相关(r值分别为0.105、0.635、0.143、0.704、0.619,P<0.01),而FT3与FPG、TC、LDL-C、HDL-C均呈负相关(r值分别为-0.568、-0.676、-0.352、-0.702、-0.764,P<0.01),FT4与FPG、TC、LDL-C、HDL-C均呈负相关(r值分别为-0.401、-0.547、-0.425、-0.639、-0.493,P<0.01)。结论血清FPG、TC、TG、LDL-C升高,HDL-C降低,为甲状腺结节诱发因素。

Objective To observe the correlation analysis between the occurrence of thyroid nodules and the level of glucose and lipid metabolism.Methods A total of 100 patients examined thyroid at Xiamen Humanity Hospital from January to December 2022 were divided into different groups based on their examination results.Among them,50 patients with thyroid nodules as the study group and 50 patients without thyroid nodules as the control group.The basic data of patients were analyzed to determine the correlation between thyroid nodules and glucose and lipid metabolism levels[fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)].Results The levels of FPG,TC,TG,and LDL-C in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Compared to the HDL-C index,there was no statistically significant difference(P>0.05).Due to the uncertainty values of FT3,FT4,and TSH,Spearman rank correlation analysis was conducted on the level data.TSH was positively correlated with FPG,TC,LDL-C,and HDL-C(r values of 0.105,0.635,0.143,0.704,0.619,P<0.01),while FT3 is negatively correlated with FPG,TC,LDL-C,and HDL-C(r values of-0.568,-0.676,-0.352,-0.702,-0.764,P<001),and FT4 was negatively correlated with FPG,TC,LDL-C,and HDL-C(r values of-0.401,-0.547,-0.425,-0.639,-0.493,P<0.01).Conclusion The increase in FPG,TC,TG,LDL-C levels and the decrease in HDL-C levels are influencing factors for inducing TNS in the body.