白葡奈氏菌片联合ICS+LABA治疗中重度COPD急性发作

Staphylococcus and Neisseria Tablet Combined With ICS+LABA in the Treatment of Patients With Acute Attack of Moderate and Severe COPD

目的探究及观察白葡奈氏菌片联合吸入糖皮质激素+长效β2受体激动剂(inhaled corticosteroid+long-acting β_(2)-agonist,ICS+LABA)治疗中重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性发作的疗效及对生活质量的影响。方法将2020年6月—2021年12月山东第一医科大学附属省立医院的80例中重度COPD急性发作患者根据随机数字表法分为2组。对照组的40例采用ICS+LABA进行治疗,观察组的40例则在对照组的基础上加用白葡奈氏菌片。比较2组的COPD治疗总有效率、不良反应发生率、治疗前后的症状体征积分、疾病状态[慢性阻塞性肺疾病评分(COPD assessment test,CAT评分)]及生活质量[世界卫生组织生存质量测定量表简表(World Health Organization on quality of life brief scale,WHOQOL-BREF评分)]。结果治疗1、2周后观察组的COPD治疗总有效率显著高于对照组,差异有统计学意义(P<0.05),2组的不良反应发生率比较,差异无统计学意义(P>0.05),治疗1、2周后观察组的COPD相关症状体征积分显著低于对照组,CAT评分构成则显著优于对照组,WHOQOL-BREF评分显著高于对照组,差异有统计学意义(P<0.05)。结论白葡奈氏菌片联合ICS+LABA治疗中重度COPD急性发作的疗效较好,且可显著改善患者的生活质量。

Objective To investigate and observe the effect of staphylococcus and neisseria tablet combined with inhaled corticosteroid+long-acting β_(2)-agonist(ICS+LABA)in the treatment of patients with acute attack of moderate and severe chronic obstructive pulmonary disease(COPD)and influence for life quality.Methods A total of 80 patients in Provincial Hospital Affiliated to Shandong First Medical University with acute attack of moderate and severe COPD from June 2020 to December 2021 were divided into the control group with 40 cases and the observation group with 40 cases by the method of random number table.The control group was treated with ICS+LABA,the observation group was treated with staphylococcus and neisseria tablet on the treatment of the control group.Then the total effective rates of COPD treatment,adverse reactions rates,symptom and sign scores,disease status[COPD assessment test(CAT score)]and life quality[World Health Organization on quality of life brief scale(WHOQOL-BREF score)]before and after the treatment of two groups were compared.Results The total effective rates of COPD treatment of observation group at 1st and 2nd week after the treatment were significantly higher than those of control group,the differences were statistically significant(P<0.05),the adverse reactions rates of two groups were compared,the differences were not statistically significant(P>0.05).At 1st and 2nd week after the treatment,the COPD related symptom and sign scores of observation group were significantly lower than those of control group,composition of CAT scores were significantly better than those of control group,the WHOQOLBREF scores were significantly higher than those of control group,the differences were statistically significant(P<0.05).Conclusion The effect of staphylococcus and neisseria tablet combined with ICS+LABA in the treatment of patients with acute attack of moderate and severe COPD is better,and it can significantly improve the life quality of patients.