非小细胞肺癌治疗中应用电视辅助胸腔镜手术的效果及对免疫功能的影响

Effect of Video-Assisted Thoracoscopic Surgery in the Treatment of Non-Small Cell Lung Cancer and Its Impact on Immune Function

目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)治疗中应用电视辅助胸腔镜手术的效果及对免疫功能的影响。方法选取2019年10月—2021年10月泉州市第一医院胸外科收治的以NSCLC为诊断的96例患者,以随机数字表法分为2组,各48例。研究组以电视辅助胸腔镜手术治疗,对照组以常规手术治疗。比较2组患者围手术期相关指标,检测2组患者术前、术后3 d时的炎症指标、免疫功能指标,统计患者术后并发症发生情况。结果研究组术中出血量少于对照组,且术后引流管留置时间、术后镇痛时间与住院时间短于对照组,差异有统计学意义(P<0.05)。2组术前的炎症指标、免疫功能指标比较,差异无统计学意义(P>0.05)。术后3 d,2组炎症指标较术前有所提升,其中研究组提升程度低于对照组,而血清免疫功能指标较术前有所下降,其中研究组下降程度低于对照组,差异有统计学意义(P<0.05)。研究组患者术后并发症总发生率为4.17%,低于对照组的18.75%,差异有统计学意义(P<0.05)。结论在NSCLC患者的治疗中以电视辅助胸腔镜手术治疗可减少术中出血量,缩短术后引流管留置时间、术后镇痛时间与住院时间,对于机体炎症指标及免疫功能指标影响较小,术后并发症发生率更低。

Objective To evaluate the therapeutic effect of videoassisted thoracoscopic surgery in the treatment of non-small cell lung cancer(NSCLC)and its impact on immune function.Methods A total of 96 patients diagnosed with NSCLC admitted to department of thoracic surgery,Quanzhou First Hospital from October 2019 to October 2021 were selected and divided into two groups by random number table method,with 48 cases in each group.The study group was treated with video-assisted thoracoscopic surgery,while the control group was treated with conventional surgery.The perioperative relevant indexes of the two groups were compared,the inflammatory indexes and immune function indexes of the two groups were detected before and 3 days after surgery,and the incidence of postoperative complications were counted.Results The intraoperative blood loss of the study group was lower than that of the control group,and the postoperative drainage catheter indentation,postoperative analgesia time and hospitalization time were shorter than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference between the two groups in preoperative inflammatory and immune function indicators(P>0.05).Three days after surgery,the inflammatory indicators in the two groups increased compared to those before surgery,with the degree of improvement in the research group being lower than that in the control group,while the serum immune function indicators decreased compared to those before surgery,with the degree of decrease in the research group being lower than that in the control group,the difference was statistically significant(P<0.05).The total incidence of postoperative complications in the study group was 4.17%,which was lower than that in the control group(18.75%),the difference was statistically significant(P<0.05).Conclusion Video-assisted thoracoscopic surgery can reduce intraoperative bleeding,shorten postoperative drainage tube indwelling time,postoperative analgesia time,and hospital stay in patients with NSCLC.It has a small impact on inflammatory and immune function indicators,and has a lower incidence of postoperative complications.