Embosphere微球栓塞子宫动脉治疗子宫腺肌症的效果及对子宫血流状态、生长因子的影响

Effect of Embosphere microspheres embolization of uterine artery in the treatment of adenomyosis and its influences on uterine blood flow and growth factors

目的探讨Embosphere微球栓塞子宫动脉治疗子宫腺肌症的临床效果。方法选取2018年4月至2021年6月收治的100例子宫腺肌症患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组50例。对照组采取腹腔镜下病灶切除术治疗,观察组采取Embosphere微球栓塞子宫动脉治疗。比较两组的治疗效果。结果治疗后,观察组的月经量少于对照组,痛经程度评分低于对照组,子宫内膜厚度小于对照组(P<0.05)。治疗后,观察组的搏动指数(PI)、阻力指数(RI)高于对照组,收缩期峰值血流速度(PSV)低于对照组(P<0.05)。治疗后,观察组的转化生长因子-β1(TGF-β1)、胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)水平低于对照组(P<0.05)。结论Embosphere微球栓塞子宫动脉治疗子宫腺肌症的效果满意,能够降低月经量与痛经程度,改善子宫内膜厚度,也可调节子宫血流状态,抑制生长因子水平。

Objective To investigate the clinical effect of Embosphere microspheres embolization of uterine artery in the treatment of adenomyosis.Methods A total of 100 patients with adenomyosis admitted from April 2018 to June 2021 were selected as the research objects and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with laparoscopic lesion resection,and the observation group was treated with Embosphere microsphere embolization of uterine artery.The therapeutic effects of the two groups were compared.Results After treatment,the menstrual volume of the observation group was less than that of the control group,the dysmenorrhea score was lower than that of the control group,and the endometrial thickness was less than that of the control group(P<0.05).After treatment,the pulsatility index(PI)and resistance index(RI)of the observation group were higher than those of the control group,and peak systolic blood velocity(PSV)was lower than that of the control group(P<0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1),insulin like growth factor-1(IGF-1)and vascular endothelial growth factor(VEGF)in the observation group were lower than those in the control group(P<0.05).Conclusion Embosphere microspheres embolization of uterine artery in the treatment of adenomyosis has satisfactory effect.It can reduce menstrual flow and dysmenorrhea,improve endometrial thickness,regulate uterine blood flow,and inhibit growth factor levels.