枳术宽中胶囊联合氟哌噻吨美利曲辛片对功能性消化不良患者中医证候及胃肠激素的影响

Effects of Zhizhu Kuanzhong capsule combined with flupentixol and melitracen tablets on TCM syndromes and gastrointestinal hormones in patients with functional dyspepsia

目的探讨枳术宽中胶囊联合氟哌噻吨美利曲辛片治疗功能性消化不良(FD)患者的临床效果。方法选取2021年2月至2022年3月我院收治的92例FD患者为研究对象,按随机数字表法将其分为对照组和观察组,各46例。对照组采用氟哌噻吨美利曲辛片治疗,观察组采用枳术宽中胶囊联合氟哌噻吨美利曲辛片治疗。比较两组的治疗效果。结果治疗后,观察组的嗳气、上腹疼痛、早饱及上腹饱胀积分低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的胃动素、胃泌素及P物质水平均高于对照组(P<0.05)。治疗后,观察组的前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TF)水平均高于对照组(P<0.05)。治疗后,观察组的生活质量综合评定问卷(GQOLI-74)各维度评分高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论枳术宽中胶囊联合氟哌噻吨美利曲辛片治疗FD患者的效果确切,能够有效减轻中医证候,改善胃肠激素水平与营养状态,提升生活质量,安全可靠。

Objective To investigate the clinical effect of Zhizhu Kuanzhong capsules combined with flupentixol and melitracen tablets in treatment of patients with functional dyspepsia(FD).Methods A total of 92 FD patients admitted in our hospital from February 2021 to March 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 46 cases in each group.The control group was treated with flupentixol and melitracen tablets,and the observation group was treated with Zhizhu Kuanzhong capsules combined with flupentixol and melitracen tablets.The therapeutic effects of the two groups were compared.Results After treatment,the scores of belching,upper abdominal pain,early satiety and upper abdominal fullness in the observation group were lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of motilin,gastrin and substance P in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of prealbumin(PA),albumin(ALB)and transferrin(TF)in the observation group were higher than those in the control group(P<0.05).After treatment,the scores of each dimension of Generic Quality of Life Inventory-74(GQOLI-74)in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Zhizhu Kuanzhong capsule combined with flupentixol and melitracen tablets is effective in the treatment of FD patients,it can effectively reduce TCM syndromes,improve gastrointestinal hormone levels and nutritional status,and promote quality of life,which is safe and reliable.