黄莪胶囊对前列腺癌根治术后膀胱功能损伤患者的治疗作用

Therapeutical effect of Huang'e capsule on bladder dysfunction after radical prostatectomy for prostate cancer

目的探讨黄莪胶囊对前列腺癌根治术后膀胱功能损伤的临床疗效。方法选取实施腹腔镜下前列腺癌根治术治疗的前列腺癌患者108例,采用随机数字表法将其分为对照组和观察组各54例。对照组术后进行常规抗生素预防感染和康复训练,观察组在对照组基础上给予黄莪胶囊治疗,疗程为42 d。观察两组住院期间的膀胱痉挛和疼痛情况。疗程结束后,采用尿动力学检查仪检测患者最大尿流量、膀胱顺应性、最大逼尿肌压力、最大尿道压,采用国际尿控协会调查问卷评估患者尿控情况、健康调查简表(SF-36)评估治疗前后生活质量、中文版癌症自我管理效能感量表(C-SUPPH)评估自我管理效能。结果与对照组比较,观察组住院期间膀胱痉挛疼痛度降低,痉挛次数、疼痛持续时间减少(P均<0.05)。治疗42 d,观察组最大尿流量、膀胱顺应性、最大逼尿肌压力和最大尿道压力较对照组升高,尿控分级优于对照组,SF-36评分、C-SUPPH各维度评分及总分均高于对照组,差异有统计学意义(P均<0.05)。结论黄莪胶囊对前列腺癌根治术后膀胱功能损伤具有一定治疗作用,可减轻患者术后膀胱痉挛症状,改善尿控和尿动力学指标,提高生活质量。

Objective To explore the clinical effect of Huang'e capsule in treatment of bladder dysfunction after rad⁃ical prostatectomy for prostate cancer.Methods A total of 108 patients with prostate cancer undergoing laparoscopic rad⁃ical prostatectomy were selected and randomly divided into the control group(54 cases)and observation group(54 cases).In the control group,routine antibiotics were administered postoperatively for infection prevention,and rehabilitation train⁃ing was conducted.In the observation group,in addition to the measures taken in the control group,Huang'e capsules were administered for a treatment course of 42 days.Spasm and pain during hospitalization were observed in both groups.After completing the course,urodynamic parameters including maximum urine flow rate,bladder compliance,maximum detrusor pressure,and maximum urethral pressure were measured using a urodynamic examination device.The Interna⁃tional Continence Society(ICS)questionnaire was used to assess urinary control,the Short Form 36(SF-36)question⁃naire was employed to evaluate the quality of life before and after treatment,and the Chinese version of Strategies Used by People to Promote Health(C-SUPPH)was used to assess self-management efficacy.Results Compared with the control group,patients in the observation group experienced a reduction in spasm pain intensity,decreased spasm frequency,and reduced duration of pain during hospitalization(all P<0.05).Compared with the control group,after 42 days of treat⁃ment,the maximum urine flow rate,bladder compliance,maximum detrusor pressure,and maximum urethral pressure in⁃creased,the urinary control grading was better,and SF-36 scores,C-SUPPH dimension scores,and total scores were high⁃er in the observation group than in the control group,with statistically significant differences(all P<0.05).Conclusions Huang'e capsules have a certain therapeutic effect on bladder dysfunction after radical prostatectomy for prostate cancer.They can reduce postoperative bladder spasms,improve urinary control and urodynamic parameters,and enhance the qual⁃ity of life for patients.