化湿解毒方治疗湿热内蕴型溃疡性结肠炎临床研究

Clinical Study on the Treatment of Ulcerative Colitis with Syndrome of Internal Retention of Dampness-Heat with Dampness-Resolving and Toxin-Removing Decoction

目的:观察化湿解毒方治疗湿热内蕴型溃疡性结肠炎的临床疗效及对患者大肠杆菌、乳酸菌和双岐杆菌等肠道菌群的影响。方法:将60例湿热内蕴型溃疡性结肠炎患者按照随机数字表法分为对照组和治疗组,每组各30例。对照组口服美沙拉嗪肠溶片,治疗组给予化湿解毒方。比较两组患者的临床疗效及治疗前后腹胀、腹痛、黏液脓血便及里急后重等临床症状积分变化情况,检测两组患者治疗前后大肠杆菌、双歧杆菌及乳酸菌等肠道菌群数量,统计两组患者治疗前后疾病活动指数(isease activity index,DAI)及内镜评分。结果:治疗组有效率为93%,对照组有效率为80%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后临床症状积分低于本组治疗前,且治疗后治疗组低于对照组(P<0.05)。两组患者治疗后肠道菌群中大肠杆菌数量低于本组治疗前,乳酸杆菌和双歧杆菌数量高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后DAI及内镜评分低于本组治疗前,且治疗后治疗组低于对照组(P<0.05)。结论:化湿解毒方治疗湿热内蕴型溃疡性结肠炎,疗效确切,可调节患者肠道菌群数量,有效改善临床症状。

Objective:To observe the clinical efficacy of Dampness-Resolving and Toxin-Removing Decoction on ulcerative colitis with syndrome of internal retention of dampness-heat and its influence on escherichia coli,lactobacillus and bifidobacterium.Methods:A total of 60 patients with ulcerative colitis with syndrome of internal retention of dampness-heat were divided into the control group and the treatment group according to the random number table method,with 30 cases in each group.The control group was given Mesalazine En-teric-Coated Tablets orally,while the treatment group was given Dampness-Resolving and Toxin-Removing Decoction.The clinical effica-cy,the changes in clinical symptom scores before and after treatment,such as abdominal distention,abdominal pain,mucus-pus-blood stool and tenesmus,etc.were compared.The disease activity index(DAIDAI)and endoscopic scores were statistically analyzed before and after treatment.Results:The effective rate of the treatment group was 93%,while that of the control group was 80%,with a statisti-cally significant difference(P<0.05).The clinical symptom scores of the two groups after treatment were lower than those before treat-ment,and the scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the number of esch-erichia coli in the intestinal flora of the two groups was lower than that before treatment,and the number of lactobacillus and bifidobacte-rium was higher than that before treatment respectively,and all the differences were statistically significant between the two groups after treatment(P<0.05).The DAI and endoscopic scores of the two groups were lower than those before treatment,and the treatment group′s scores were lower than those of the control group(P<0.05).Conclusion:Dampness-Resolving and Toxin-Removing Decoction in the treatment of ulcerative colitis with syndrome of internal retention of dampness-heat has definite clinical efficacy,can regulate the number of intestinal flora in patients and effectively improve clinical symptoms.