趋化因子受体9/趋化因子配体25在相关疾病中的研究进展

Research progress of CC chemokine receptor 9/CC chemokine ligand 25in related diseases

趋化因子是一类分子量相对较小的结构相关蛋白,能定向诱导免疫细胞趋化,促进炎症反应。趋化因子受体9(CCR9)和趋化因子配体25(CCL25)参与调节多种疾病的发生及发展。早期研究表明,CCR9参与炎症细胞的迁移及成熟等生理过程,后来的研究证实,CCR9/CCL25在各种炎症及非炎症疾病中如炎症性肠病、类风湿性关节炎及心血管疾病、肿瘤等疾病的病理过程中发挥重要作用。因此,本综述概述了CCR9/CCL25在各类疾病中的最新进展,有利于对CCR9/CCL25深入研究,CCR9/CCL25有望成为药物治疗的潜在靶点。

Chemokine is a structure-related protein with a relatively small molecular weight,which can target cells to chemotaxis and promote inflammatory response.CC chemokine receptor 9(CCR9)and CC chemokine ligand 25(CCL25)are involved in the regulating the occurrence and development of various diseases.Early research have confirmed various physiological functions including migration and maturation of inflammatory cells.Subsequent studies have confirmed that CCR9/CCL25 plays an important role in the pathological processes of various inflammatory and non inflammatory diseases such as inflammatory bowel disease,rheumatoid arthritis,cardiovascular disease,tumors,and other diseases.Therefore,this review provides an overview of the latest progress of CCR9/CCL25 in various diseases,which is beneficial for in-depth research on CCR9/CCL25.CCR9/CCL25 is expected to become a potential target for drug therapy.