类风湿关节炎合并间质性肺疾病的发病机制的研究进展

Research progress on pathogenesis of rheumatoid arthritis combined with interstitial lung disease

类风湿关节炎合并间质性肺疾病有较高的发病率及死亡率,临床中研究其发病机制意义重大,可为该病的靶点治疗提供证据,早期有效控制病情,提高患者生存质量,降低死亡率。此外,研究参与致病的危险因素可为高危人群预防提供证据,早期预防及诊断,对改善疾病预后有较大意义。本文主要从吸烟人群易感性、微生物病原体等环境层面,基因易感性、基因变异等基因层面,以及自身抗体及免疫细胞、细胞因子等分子层面进行综述,具体阐释多种因素参与类风湿关节炎合并间质性肺病的发病机制。

Rheumatoid arthritis combined with interstitial lung disease has a high incidence and mortality.Clinical research on its pathogenesis is of great significance,which can provide evidence for the targeted treatment of the disease,effectively control the disease early,improve the quality of life of patients,and reduce the mortality.In addition,research on the risk factors involve in the disease can provide evidence for the prevention of high-risk groups,early prevention,and diagnosis.It is of great significance to improve the prognosis of the disease.This paper mainly reviewes the environmental level of smoking population susceptibility,microbial pathogens,gene level of genetic susceptibility,gene variation,and molecular level of autoantibodies,immune cells and cytokines,and elaborated on the pathogenesis of various factors involved in rheumatoid arthritis complicated with interstitial lung disease.