胰岛素抵抗新机制的研究进展

Research progress on new mechanisms of insulin resistance

胰岛素抵抗与多囊卵巢综合征、非酒精性脂肪肝和2型糖尿病等多种代谢性疾病的发生及发展相关。随着生活水平的提高,肥胖和胰岛素抵抗出现的概率日益升高。关于胰岛敏感性的研究得到了越来越多的重视,重点在于胰岛素抵抗机制的研究,目前胰岛素抵抗的机制除了脂质超载和炎症外,还有一系列应激反应、胰岛素信号通路上物质的分子水平突变、自噬及肠道菌群失调等。现已发表的文章对胰岛素抵抗机制的阐述不够全面,因此,本文从以上多方面对现有的胰岛素抵抗发生机制进行了综述。

Insulin resistance is related to the occurrence and development of various metabolic diseases such as polycystic ovary syndrome,non-alcoholic fatty liver disease,and type two diabetes mellitus.With the improvement of living standards,the probability of obesity and insulin resistance is increasing.The research on insulin sensitivity has received increasing attention,with a focus on the mechanism of insulin resistance.At present,the mechanism of insulin resistance is not only lipid overload and inflammation,but also a series of stress reactions,molecular level mutations of substances in the insulin signaling pathway,autophagy,and intestinal microbiota imbalance.The published articles on the mechanism of insulin resistance are not comprehensive enough,therefore,this article reviews the existing mechanisms of insulin resistance from multiple aspects mentioned above.